Understanding the Concept of Pre-Clinical Autoimmunity: Prediction and Prevention of Systemic Lupus Erythematosus: Identifying Risk Factors and Developing Strategies Against Disease Development.
Understanding the Concept of Pre-Clinical Autoimmunity: Prediction and Prevention of Systemic Lupus Erythematosus: Identifying Risk Factors and Developing Strategies Against Disease Development.
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DOI：
10.3389/fimmu.2022.890522
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
越来越多的证据表明，在系统性红斑狼疮（SLE）的诊断或分类之前，患者经历了疾病的临床前阶段，炎症和自身免疫标志物已经存在。不足为奇的是，尽管多年来SLE的管理已经有所改善，但许多患者在被诊断为SLE时已经有了不可逆的疾病相关器官损害。通过对临床前SLE发病机制的更深入了解，我们可以在病程早期识别有转变为全面SLE风险的患者，并实施预防策略。在这篇综述中，我们讨论了SLE临床前发病机制的现状，并提出了一种筛查和预防策略，包括使用有前途的早期疾病生物标志物，改变生活方式和环境风险因素，以及开始预防性治疗，正如在其他自身免疫性疾病如类风湿关节炎和1型糖尿病中所检查的那样。
There is growing evidence that preceding the diagnosis or classification of systemic lupus erythematosus (SLE), patients undergo a preclinical phase of disease where markers of inflammation and autoimmunity are already present. Not surprisingly then, even though SLE management has improved over the years, many patients will already have irreversible disease-related organ damage by time they have been diagnosed with SLE. By gaining a greater understanding of the pathogenesis of preclinical SLE, we can potentially identify patients earlier in the disease course who are at-risk of transitioning to full-blown SLE and implement preventative strategies. In this review, we discuss the current state of knowledge of SLE preclinical pathogenesis and propose a screening and preventative strategy that involves the use of promising biomarkers of early disease, modification of lifestyle and environmental risk factors, and initiation of preventative therapies, as examined in other autoimmune diseases such as rheumatoid arthritis and type 1 diabetes.
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影响因子：
27.4
作者：
Abelson AK;Delgado-Vega AM;Kozyrev SV;Sánchez E;Velázquez-Cruz R;Eriksson N;Wojcik J;Linga Reddy MV;Lima G;D'Alfonso S;Migliaresi S;Baca V;Orozco L;Witte T;Ortego-Centeno N;AADEA group;Abderrahim H;Pons-Estel BA;Gutiérrez C;Suárez A;González-Escribano MF;Martin J;Alarcón-Riquelme ME
通讯作者：
Alarcón-Riquelme ME
影响因子：
4.7
作者：
Barbhaiya, Medha;Lu, Bing;Sparks, Jeffrey A.;Malspeis, Susan;Chang, Shun-Chiao;Karlson, Elizabeth W.;Costenbader, Karen H.
通讯作者：
Costenbader, Karen H.
影响因子：
2.6
作者：
Avalos, I.;Chung, C. P.;Stein, C. M.
通讯作者：
Stein, C. M.
影响因子：
158.5
作者：
Arbuckle, MR;McClain, MT;Harley, JB
通讯作者：
Harley, JB
DOI：
10.1002/art.24398
发表时间：
2009-04-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Bernier, Marie-Odile;Mikaeloff, Yann;Suissa, Samy
通讯作者：
Suissa, Samy