Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts.
Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts.
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DOI：
10.1002/acr.22945
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发表时间：
2017-03
影响因子：
4.7
通讯作者：
Costenbader, Karen H.
中科院分区：
文献类型：
--
作者：
Barbhaiya, Medha;Lu, Bing;Sparks, Jeffrey A.;Malspeis, Susan;Chang, Shun-Chiao;Karlson, Elizabeth W.;Costenbader, Karen H.
适量饮酒具有抗炎作用，并与降低心血管疾病和类风湿性关节炎的风险有关。我们调查了护士健康研究（NHS）队列中女性饮酒与SLE风险之间的关系。我们对NHS（1980-2012）和NHSII（1989-2011）中的204，055名女性进行了前瞻性队列分析，这些女性没有结缔组织疾病并在基线时提供了酒精信息。每2-4年使用半定量食物频率问卷评估酒精消费。我们通过自我报告后的病历审查来验证SLE事件。考克斯比例风险模型基于累积平均酒精摄入量估计SLE的风险比，调整潜在的混杂因素。使用DerSimonian和Laird随机效应模型对结果进行荟萃分析。我们进一步研究了与葡萄酒、啤酒和白酒摄入相关的SLE风险。我们确定了NHS中的125例SLE事件和NHSII中的119例。NHS和NHSII中SLE诊断时的平均年龄分别为55.8（SD 9.5）岁和43.4（SD 7.7）岁。与不饮酒相比，累积饮酒量≥5 g/天的荟萃分析多变量HR为0.61（95%CI 0.41-0.89）。当限制SLE诊断前4年的酒精暴露时，多变量HR相似，为0.61（95%CI 0.41-0.91）。与不饮酒的女性相比，每周饮酒≥2次的女性SLE风险显著降低（HR 0.65; 95%CI 0.45-0.96）。在这些大型前瞻性队列中，我们证明了女性中度饮酒（≥5克或0.5杯/天）与SLE风险之间的负相关性。
Moderate alcohol consumption has anti-inflammatory properties and is associated with reduced cardiovascular disease and rheumatoid arthritis risks. We investigated the association between alcohol consumption and SLE risk among women followed in the Nurses’ Health Study (NHS) cohorts. We conducted a prospective cohort analysis among 204,055 women in NHS (1980–2012) and NHSII (1989–2011), free of connective tissue disease and providing alcohol information at baseline. Alcohol consumption was assessed using a semi-quantitative food frequency questionnaire every 2–4 years. We validated incident SLE through medical record review after self-report. Cox proportional hazards models estimated hazard ratios for SLE based on cumulative average alcohol intake, adjusting for potential confounders. Results were meta-analyzed using DerSimonian and Laird random effects models. We further investigated SLE risk associated with wine, beer, and liquor intake. We identified 125 incident SLE cases in NHS and 119 in NHSII. Mean age at SLE diagnosis was 55.8 (SD 9.5) years in NHS and 43.4 (SD 7.7) years in NHSII. Compared to no alcohol intake, the meta-analyzed multivariable HR for cumulative alcohol consumption ≥5 grams/day was 0.61 (95%CI 0.41–0.89). When limiting alcohol exposure to >4 years prior to SLE diagnosis, the multivariable HR was similar, 0.61 (95%CI 0.41–0.91). Women who drank ≥2 servings/week of wine had significantly decreased SLE risk (HR 0.65; 95%CI 0.45–0.96), compared to women who did not drink wine. In these large prospective cohorts, we demonstrated an inverse association between moderate alcohol consumption (≥5 grams or 0.5 drink/day) and SLE risk in women.
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影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
DOI：
10.1136/bmj.h4238
发表时间：
2015-08-18
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Cao Y;Willett WC;Rimm EB;Stampfer MJ;Giovannucci EL
通讯作者：
Giovannucci EL
影响因子：
8.8
作者：
Je, Y.;DeVivo, I.;Giovannucci, E.
通讯作者：
Giovannucci, E.
DOI：
10.1136/bmj.d671
发表时间：
2011-02-22
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Ronksley PE;Brien SE;Turner BJ;Mukamal KJ;Ghali WA
通讯作者：
Ghali WA
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N