Music therapy, neural processing, and craving reduction: an RCT protocol for a mixed methods feasibility study in a Community Substance Misuse Treatment Service.
Music therapy, neural processing, and craving reduction: an RCT protocol for a mixed methods feasibility study in a Community Substance Misuse Treatment Service.
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DOI：
10.1186/s13722-023-00385-y
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发表时间：
2023-05-27
影响因子：
3.7
通讯作者：
Odell-Miller, Helen
中科院分区：
文献类型：
--
作者：
Fachner, Jorg;Maidhof, Clemens;Murtagh, Daniel;De Silva, Devon;Pasqualitto, Filippo;Fernie, Paul;Panin, Francesca;Michell, Andrew;Muller-Rodriguez, Leonardo;Odell-Miller, Helen
关键词：
音乐疗法已被证明对与物质使用障碍相关的多个临床终点有效，例如减少渴望、情绪调节、缓解抑郁和焦虑，但缺乏在英国社区物质滥用治疗服务机构（CSMTSs）中对这些效果进行研究的相关研究。此外，在物质使用障碍治疗方面，需要确定音乐疗法的改变机制以及相关的大脑过程。本研究旨在评估音乐疗法以及一套前测、后测和治疗过程中的测量组合在社区物质滥用治疗服务机构中的可行性和可接受性。
来自伦敦一个社区服务机构的15名参与者将参加一项混合方法的非盲随机对照试验。10名参与者除了接受社区物质滥用治疗服务机构提供的标准治疗外，还将接受为期六周的音乐疗法治疗——其中5人将接受个体音乐疗法，另外5人将接受团体音乐疗法——而另外5名参与者将作为对照组，仅接受标准治疗。
在最后一次治疗结束后，将通过焦点小组与服务使用者和工作人员一起评估满意度和可接受性。此外，在整个干预过程中，将对出勤率和完成率进行监测。在干预前后将对主观和行为指标进行评估，以探究音乐疗法对渴望、物质使用、抑郁和焦虑症状以及抑制控制的影响，并将其与相关的神经生理特征相关联。对两次个体音乐疗法治疗过程的分析将用于探究在治疗过程中大脑是如何处理音乐和情绪的。每一步收集的数据都将纳入意向性分析。
这项研究将首次报告音乐疗法作为一种干预措施，对参与社区服务的物质使用障碍参与者的可行性。它还将提供关于在这一群体中实施包括神经生理学、问卷调查和行为评估在内的多层面方法的有价值信息。尽管样本量较小存在局限性，但本研究将提供关于接受音乐疗法的物质使用障碍参与者神经生理学结果的新的初步数据。
试验注册：ClinicalTrails.gov，NCT0518061，2022年1月6日注册，https://clinicaltrials.gov/ct2/show/NCT05180617
Music therapy has been shown to be effective for multiple clinical endpoints associated with substance use disorder such as craving reduction, emotion regulation, depression, and anxiety, but there are a lack of studies investigating those effects in UK Community Substance Misuse Treatment Services (CSMTSs). Furthermore, there is a demand for identifying music therapy mechanisms of change and related brain processes for substance use disorder treatment. The present study aims to evaluate the feasibility and acceptability of music therapy and a pre-test, post-test, and in-session measurement battery in a CSMTS. Fifteen participants, from a community service based in London, will take part in a mixed-methods non-blind randomized-controlled trial. Ten participants will receive six-weekly sessions of music therapy in addition to the standard treatment offered by the CSMTS—five of them will receive individual music therapy and five of them will receive group music therapy—while a further five participants will act as a control group receiving standard treatment only. Satisfaction and acceptability will be evaluated in focus groups with service users and staff members following the final treatment session. Moreover, attendance and completion rates will be monitored throughout the intervention. Subjective and behavioral indexes will be assessed before and after the interventions to explore the effects of music therapy on craving, substance use, symptoms of depression and anxiety, inhibitory control, and will be correlated with associated neurophysiological signatures. In-session analysis of two individual music therapy sessions will serve to explore how music and emotion are processed in the brain within the therapy. The data collected at each step will be included in an intention-to-treat analysis basis. This study will provide a first report on the feasibility of music therapy as an intervention for participants with substance use disorder engaged within a community service. It will also provide valuable information regarding the implementation of a multifaceted methodology that includes neurophysiological, questionnaire-based, and behavioral assessments in this cohort. Notwithstanding the limitation of a small sample size, the present study will provide novel preliminary data regarding neurophysiological outcomes in participants with substance use disorder that received music therapy. Trial Registration: ClinicalTrails.gov, NCT0518061, Registered 6 January 2022, https://clinicaltrials.gov/ct2/show/NCT05180617
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