White matter microstructural alterations in children with prenatal methamphetamine/polydrug exposure.
White matter microstructural alterations in children with prenatal methamphetamine/polydrug exposure.
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DOI：
10.1016/j.pscychresns.2012.04.017
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发表时间：
2012-11-30
影响因子：
11.3
通讯作者：
Sowell ER
中科院分区：
文献类型：
--
作者：
Colby JB;Smith L;O'Connor MJ;Bookheimer SY;Van Horn JD;Sowell ER
关于产前甲基苯丙胺暴露对白色物质微观结构的影响以及伴随的酒精暴露的影响知之甚少。对21名产前接触甲基苯丙胺的儿童（年龄9.8±1.8岁; 17名也接触酒精），19名产前接触酒精但未接触甲基苯丙胺的儿童（年龄10.8±2.3岁）和27名发育正常的儿童（年龄10.3±3.3岁）进行了弥散张量成像和神经认知测试。分数各向异性（FA）的全脑地图进行了评估，使用基于轨迹的空间统计。相对于未暴露的对照组，产前甲基苯丙胺暴露的儿童表现出较高的FA主要在左侧区域，包括左前放射冠（LCR）和皮质脊髓束（P<0.05，校正）。这些FA差异的事后分析表明，它们可能更多地是由较低的径向扩散率（RD）而不是较高的轴向扩散率（AD）引起的。相对于甲基苯丙胺暴露组，产前酒精暴露儿童的额颞区FA较低-特别是右侧外囊（P<0.05，校正）。在预测FA时，我们没有发现任何组-表现相互作用（执行功能和视觉整合测试）;然而，右外囊的FA与各组视觉整合测试的表现显著相关（P<0.05）。本报告证明了产前甲基苯丙胺/多种药物暴露的儿童中独特的扩散异常，与仅与酒精暴露相关的异常不同，并说明这些脑微结构异常持续到儿童期和青春期-在子宫内多种药物暴露后很长时间。
Little is known about the effects of prenatal methamphetamine exposure on white matter microstructure, and the impact of concomitant alcohol exposure. Diffusion tensor imaging and neurocognitive testing were performed on 21 children with prenatal methamphetamine exposure (age 9.8±1.8 years; 17 also exposed to alcohol), 19 children with prenatal alcohol but not methamphetamine exposure (age 10.8±2.3 years), and 27 typically-developing children (age 10.3±3.3 years). Whole-brain maps of fractional anisotropy (FA) were evaluated using tract-based spatial statistics. Relative to unexposed controls, children with prenatal methamphetamine exposure demonstrated higher FA mainly in left-sided regions, including the left anterior corona radiata (LCR) and corticospinal tract (P<0.05, corrected). Post-hoc analyses of these FA differences showed they likely result more from lower radial diffusivity (RD) than higher axial diffusivity (AD). Relative to the methamphetamine-exposed group, children with prenatal alcohol exposure showed lower FA in frontotemporal regions – particularly the right external capsule (P<0.05, corrected). We failed to find any group-performance interaction (on tests of executive functioning and visuomotor integration) in predicting FA; however, FA in the right external capsule was significantly associated with performance on a test of visuomotor integration across groups (P<0.05). This report demonstrates unique diffusion abnormalities in children with prenatal methamphetamine/polydrug exposure that are distinct from those associated with alcohol exposure alone, and illustrates that these abnormalities in brain microstructure are persistent into childhood and adolescence – long after the polydrug exposure in utero.
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影响因子：
5.8
作者：
Lebel, Catherine;Roussotte, Florence;Sowell, Elizabeth R.
通讯作者：
Sowell, Elizabeth R.
DOI：
10.1097/dbp.0b013e3181a7ee6b
发表时间：
2009-06
期刊：
Journal of developmental and behavioral pediatrics : JDBP
影响因子：
--
作者：
Lu LH;Johnson A;O'Hare ED;Bookheimer SY;Smith LM;O'Connor MJ;Sowell ER
通讯作者：
Sowell ER
影响因子：
8
作者：
Fryer, Susanna L.;McGee, Christie L.;Mattson, Sarah N.
通讯作者：
Mattson, Sarah N.
影响因子：
--
作者：
Kortte, Kathleen Bechtold;Horner, Michael David;Windham, Whitney K
通讯作者：
Windham, Whitney K
影响因子：
5.9
作者：
O'Connor, Mary J.;Frankel, Fred;Marquardt, Renee
通讯作者：
Marquardt, Renee