Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for Diabetes.
Widely Targeted Metabolomics Analysis of Soybean and Chickpea and Their Different Advantages and New Functional Compounds for Diabetes.
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大豆和鹰嘴豆的广泛靶向代谢组学分析及其不同优势和治疗糖尿病的新功能化合物。
DOI：
10.3390/molecules27165297
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发表时间：
2022-08-19
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影响因子：
--
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大豆是一种广泛用于日常消费的豆类。鹰嘴豆因其良好的保健功能而得到越来越多的利用。目前，在某些地区使用鹰嘴豆可能比使用大豆效果更好。之前对这两种豆类的研究主要集中在某些成分上，未能完全揭示这两种豆类之间的差异。因此，全面了解这两种豆科植物的异同，对于有效地利用和开发这两种豆科植物是必要的。在这项研究中，我们对两种豆科植物进行了基于UPLC-ESI-MS/MS的广泛靶向代谢组学分析。共检测到776种代谢物(包括初级代谢物和次级代谢物)，分为十几大类。这些代谢物的差异分析表明，两种豆科植物之间有480种代谢物的相对含量存在显著差异。与大豆相比，鹰嘴豆的374个代谢物表达下调，106个代谢物表达上调。代谢途径分析表明，两种豆科牧草在黄酮类化合物合成、苯丙烷类化合物合成、亚油酸代谢和生物碱生物合成方面存在显著差异。通过对两种豆类抗糖尿病成分的分析，证实了这两种豆类的优势和适用性。此外，在鹰嘴豆中还发现了一些具有降血糖活性的新化合物(含量高于大豆)。本研究为大豆和鹰嘴豆的深入研究和比较应用提供了重要参考。
Soybean is widely used as a kind of bean for daily consumption. Chickpea is increasingly utilised because of its good healthcare function. At present, using chickpeas could have better results than soybeans in some areas. Previous studies of the two legumes focused on certain components and failed to fully reveal the differences between the two legumes. Thus, understanding the comprehensive similarities and differences between the two legumes is necessary to apply and develop these legumes effectively. In this study, we performed a UPLC-ESI-MS/MS-based widely targeted metabolomics analysis on two legumes. A total of 776 metabolites (including primary metabolites and secondary metabolites) were detected, which were divided into more than a dozen broad categories. The differential analysis of these metabolites showed that there were 480 metabolites with significant differences in relative contents between the two legumes. Compared with soybean, the expression of 374 metabolites of chickpea was down-regulated and that of 106 metabolites was up-regulated. The metabolic pathway analysis showed significant differences in the flavonoids biosynthesis, phenylpropanoid biosynthesis, linoleic acid metabolism and alkaloid biosynthesis between the two legumes. The advantages and applicability of the two kinds of legumes were confirmed through the analysis of anti-diabetic components. Moreover, some novel compounds (with contents higher than that of soybean) with hypoglycaemic activity were found in chickpea. This study provides an important reference for the in-depth study and comparative application of soybean and chickpea.
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