Association of grey matter changes with stability and flexibility of prediction in akinetic-rigid Parkinson’s disease
Association of grey matter changes with stability and flexibility of prediction in akinetic-rigid Parkinson’s disease
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灰质变化与运动不能性-僵硬性帕金森病预测的稳定性和灵活性的关联
DOI：
10.1007/s00429-018-1616-2
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发表时间：
2018
影响因子：
3.1
通讯作者：
Schubotz
中科院分区：
文献类型：
--
作者：
Trempler;Binder;El-Sourani;Schiffler;Tenberge;Schiffer;G. R. ;Schubotz
帕金森病(PD)是由中脑多巴胺能神经元退化引起的，导致包括认知能力下降在内的不同临床症状。由于多巴胺神经元的时相信号被认为是通过表示受试者的期望与外部事件之间的不匹配来指导学习的，因此我们在这里调查了无轻度认知障碍的僵硬型PD患者在处理相关(需要灵活性)或无关(需要稳定性)预测错误时是否表现出困难。在我们之前关于预测的灵活性和稳定性的研究(Trempler等人)之后。J Cogn Neurosci 29(2)：298-309,2017)，然后我们评估缺陷是否与多巴胺能区以及下额叶皮质、内侧前额叶皮质和海马区的特定结构变化相对应。21名健康对照和21名接受和停药治疗的僵硬PD患者完成了一项需要连续预测即将到来的项目的任务。可预测序列之间的切换必须通过按下按钮来指示，而序列遗漏则必须被忽略。与疾病无关，中脑体积与对意外事件的总体反应偏差有关，而右壳核体积与区分相关和无关预测错误的能力相关。然而，与健康受试者相比，患者对不相关的预测错误表现出稳定性缺陷，这与右额下回和左侧前额叶皮质的厚度有关。与对照组相比，患者由于相关预测误差而导致的灵活更新也受到影响，并与右侧海马体体积相关。多巴胺能药物影响患者的行为表现，但不影响患者内部。我们的探索性研究值得进一步研究缺陷的预测错误处理及其结构相关性，作为疾病早期已经出现的认知症状的核心。
Parkinson’s disease (PD), which is caused by degeneration of dopaminergic neurons in the midbrain, results in a heterogeneous clinical picture including cognitive decline. Since the phasic signal of dopamine neurons is proposed to guide learning by signifying mismatches between subjects’ expectations and external events, we here investigated whether akinetic-rigid PD patients without mild cognitive impairment exhibit difficulties in dealing with either relevant (requiring flexibility) or irrelevant (requiring stability) prediction errors. Following our previous study on flexibility and stability in prediction (Trempler et al. J Cogn Neurosci 29(2):298–309, 2017), we then assessed whether deficits would correspond with specific structural alterations in dopaminergic regions as well as in inferior frontal cortex, medial prefrontal cortex, and the hippocampus. Twenty-one healthy controls and twenty-one akinetic-rigid PD patients on and off medication performed a task which required to serially predict upcoming items. Switches between predictable sequences had to be indicated via button press, whereas sequence omissions had to be ignored. Independent of the disease, midbrain volume was related to a general response bias to unexpected events, whereas right putamen volume correlated with the ability to discriminate between relevant and irrelevant prediction errors. However, patients compared with healthy participants showed deficits in stabilisation against irrelevant prediction errors, associated with thickness of right inferior frontal gyrus and left medial prefrontal cortex. Flexible updating due to relevant prediction errors was also affected in patients compared with controls and associated with right hippocampus volume. Dopaminergic medication influenced behavioural performance across, but not within the patients. Our exploratory study warrants further research on deficient prediction error processing and its structural correlates as a core of cognitive symptoms occurring already in early stages of the disease.
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影响因子：
2
作者：
Chen, Janice;Olsen, Rosanna K.;Wagner, Anthony D.
通讯作者：
Wagner, Anthony D.
影响因子：
24.8
作者：
D'Esposito M;Postle BR
通讯作者：
Postle BR
帕金森病运动和认知功能障碍的联合原理
影响因子：
2.6
作者：
Schönberger;Hagelweide;Schubotz
通讯作者：
Schubotz
DOI：
10.1073/pnas.200033797
发表时间：
2000-09-26
影响因子：
11.1
作者：
Fischl, B;Dale, AM
通讯作者：
Dale, AM
影响因子：
4.1
作者：
Cerasa, Antonio;Morelli, Maurizio;Quattrone, Aldo
通讯作者：
Quattrone, Aldo