Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms.
Loss of skills and onset patterns in neurodevelopmental disorders: Understanding the neurobiological mechanisms.
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DOI：
10.1002/aur.1903
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Zwaigenbaum L
中科院分区：
文献类型：
--
作者：
Thurm A;Powell EM;Neul JL;Wagner A;Zwaigenbaum L
自自闭症谱系障碍首次被报道以来，人们已经确定了其发病模式，其中包括一种涉及丧失先前已获得技能的模式。然而，对这种“退化”的研究尝试一直局限于临床研究，直到最近，这些研究大多还只是回顾性报告。本报告反映了2016年美国国家心理健康研究所（NIMH）召开的一次会议上的讨论情况，该会议旨在将自闭症临床研究与该领域的基础研究和转化研究相结合。本综述描述了临床研究方面该领域的现状，阐述了基于有限方法和所收集的前瞻性数据而存在的知识缺口。讨论了在特定条件下已被证明可解释发育早期退化的生物学机制，以及尚未被探索的潜在机制。建议包括在发育期间使用模型系统以及采用前沿方法，包括非侵入性成像，这可能为更好地理解导致先前已获得技能丧失的神经生物学途径提供机会。
Patterns of onset in Autism Spectrum Disorder, including a pattern that includes loss of previously acquired skills, have been identified since the first reports of the disorder. However, attempts to study such “regression” have been limited to clinical studies, that until recently mostly involved retrospective reports. The current report reflects discussion that occurred at an NIMH convened meeting in 2016 with the purpose of bridging clinical autism research with basic and translational work in this area. This summary describes the state of the field with respect to clinical studies, describing gaps in knowledge based on limited methods and prospective data collected. Biological mechanisms that have been shown to account for regression early in development in specific conditions are discussed, as well as potential mechanisms that have not yet been explored. Suggestions include use of model systems during the developmental period and cutting-edge methods, including non-invasive imaging, that may afford opportunities for a better understanding of the neurobiological pathways that result in loss of previously-attained skills.
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DOI：
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发表时间：
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