14-3-3 Proteins in Glutamatergic Synapses.

14-3-3 Proteins in Glutamatergic Synapses.
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DOI:
10.1155/2018/8407609
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发表时间:
2018
期刊:
影响因子:
3.1
通讯作者:
Zhou Y
Zhou Y
中科院分区:
医学4区
文献类型:
--
作者:
Zhang J;Zhou Y

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14-3-3蛋白是一个在大脑中高度表达的蛋白家族,尤其在突触中富集。近二十年来积累的证据表明14-3-3蛋白是突触传递和可塑性的重要调节因子。在这里,我们将回顾以前和最近的研究,这些研究帮助我们了解14-3-3蛋白在谷氨酸突触中的作用。未来的一个关键挑战是描述参与调节突触功能的14-3-3依赖分子途径。
The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions.
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