Extracallosal Structural Connectivity Is Positively Associated With Language Performance in Well-Performing Children Born Extremely Preterm.
Extracallosal Structural Connectivity Is Positively Associated With Language Performance in Well-Performing Children Born Extremely Preterm.
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外质结构连通性与表现出色的儿童出生的良好的早产相关。
DOI：
10.3389/fped.2022.821121
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发表时间：
2022
影响因子：
2.6
通讯作者：
Kadis DS
中科院分区：
文献类型：
--
作者：
Barnes-Davis ME;Williamson BJ;Merhar SL;Nagaraj UD;Parikh NA;Kadis DS
极早产儿（小于28周妊娠）有语言发育迟缓或障碍的风险。早产儿的结构连接性降低与语言结果不良有关。以前，我们使用多模态成像技术来证明，在故事听任务中增加功能连接与早产儿的语言成绩呈正相关。与足月出生的儿童相比，这种功能连接得到了胼胝体外结构超连接的支持。在这里，我们试图在一个表现良好的极早产儿（EPT，n = 16）与长期比较（TC，n = 28）的不同队列中验证这一发现，并将其与一组有语言延迟或障碍史的极早产儿（EPT-HLD，n = 8）的结构连接进行比较。所有参与者都是4-6岁。我们进行q空间的同构重建和功能约束的结构连接（基于功能磁共振成像激活），包括一个新的扩展，使组间比较与非参数方差分析。两组在年龄、性别、种族、民族、父母教育程度、家庭收入或语言得分方面没有显著差异。对于EPT，与语言评分呈正相关的轨迹包括双侧后下额枕束和双侧小脑脚以及额外的小脑白色物质。这些通路的定量各向异性占EPT组标准化语言评分方差的55%。未来的工作将扩大这一队列，并纵向跟踪调查环境因素对早产儿大脑语言网络和弹性发展的影响。
Children born extremely preterm (<28 weeks gestation) are at risk for language delay or disorders. Decreased structural connectivity in preterm children has been associated with poor language outcome. Previously, we used multimodal imaging techniques to demonstrate that increased functional connectivity during a stories listening task was positively associated with language scores for preterm children. This functional connectivity was supported by extracallosal structural hyperconnectivity when compared to term-born children. Here, we attempt to validate this finding in a distinct cohort of well-performing extremely preterm children (EPT, n = 16) vs. term comparisons (TC, n = 28) and also compare this to structural connectivity in a group of extremely preterm children with a history of language delay or disorder (EPT-HLD, n = 8). All participants are 4–6 years of age. We perform q-space diffeomorphic reconstruction and functionally-constrained structural connectometry (based on fMRI activation), including a novel extension enabling between-groups comparisons with non-parametric ANOVA. There were no significant differences between groups in age, sex, race, ethnicity, parental education, family income, or language scores. For EPT, tracks positively associated with language scores included the bilateral posterior inferior fronto-occipital fasciculi and bilateral cerebellar peduncles and additional cerebellar white matter. Quantitative anisotropy in these pathways accounted for 55% of the variance in standardized language scores for the EPT group specifically. Future work will expand this cohort and follow longitudinally to investigate the impact of environmental factors on developing language networks and resiliency in the preterm brain.
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影响因子：
11.2
作者：
Ball G;Aljabar P;Nongena P;Kennea N;Gonzalez-Cinca N;Falconer S;Chew ATM;Harper N;Wurie J;Rutherford MA;Counsell SJ;Edwards AD
通讯作者：
Edwards AD
DOI：
10.1097/dbp.0b013e3181e5ab7e
发表时间：
2010-10-01
影响因子：
2.4
作者：
Foster-Cohen, Susan H.;Friesen, Myron D.;Woodward, Lianne J.
通讯作者：
Woodward, Lianne J.
影响因子：
5.7
作者：
Constable, R. Todd;Vohr, Betty R.;Scheinost, Dustin;Benjamin, Jennifer R.;Fulbright, Robert K.;Lacadie, Cheryl;Schneider, Karen C.;Katz, Karol H.;Zhang, Heping;Papademetris, Xenophon;Ment, Laura R.
通讯作者：
Ment, Laura R.
影响因子：
5.7
作者：
Batalle D;Hughes EJ;Zhang H;Tournier JD;Tusor N;Aljabar P;Wali L;Alexander DC;Hajnal JV;Nosarti C;Edwards AD;Counsell SJ
通讯作者：
Counsell SJ
影响因子：
5.1
作者：
Barre, Natalie;Morgan, Angela;Anderson, Peter J.
通讯作者：
Anderson, Peter J.