A Scoping Analysis of Cathelicidin in Response to Organic Dust Exposure and Related Chronic Lung Illnesses.
A Scoping Analysis of Cathelicidin in Response to Organic Dust Exposure and Related Chronic Lung Illnesses.
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DOI：
10.3390/ijms23168847
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发表时间：
2022-08-09
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
全球超过 20 亿人接触有机粉尘，可能导致呼吸系统疾病。抗菌素肽的发现为肺部对有机粉尘的反应提供了新的见解。然而，它在肺部对有机粉尘暴露和慢性肺部疾病的反应中的作用仍然有限。我们进行了范围界定审查，以绘制有关抗菌肽 LL-37/CRAMP 在应对有机粉尘暴露和相关慢性肺部疾病（过敏性肺炎 (HP)、慢性阻塞性肺病 (COPD) 和哮喘）中作用的当前证据。我们在这次审查中总共纳入了 n = 53 篇同行评审文章，遵循以下过程：(i) 初步筛选； (ii) 系统的 MEDLINE/PubMed 数据库检索； (iii) 标题、摘要和全文筛选； (iv) 数据提取和图表。在所有研究的临床环境中，导管素水平都发生了变化；其多效性功能得到证实。研究发现，导管素除了对微生物负荷和感染发挥积极作用外，还有助于维持体内平衡并参与肺损伤反应和修复。此外，LL-37被发现可以维持持续的炎症、增加粘液形成并抑制微生物和皮质类固醇。此外，研究还调查了导管素作为一种治疗方式，例如在实验性 HP 中吸入导管素，具有积极的效果。然而，纳入文章的主要焦点是 LL-37 的抗菌作用，从而得出结论：LL-37 的有益活性尚未得到充分研究，需要进一步研究。
Over two billion people worldwide are exposed to organic dust, which can cause respiratory disorders. The discovery of the cathelicidin peptide provides novel insights into the lung’s response to organic dust; however, its role in the lung’s response to organic dust exposure and chronic lung diseases remains limited. We conducted a scoping review to map the current evidence on the role of cathelicidin LL-37/CRAMP in response to organic dust exposure and related chronic lung diseases: hypersensitivity pneumonitis (HP), chronic obstructive pulmonary disease (COPD) and asthma. We included a total of n = 53 peer-reviewed articles in this review, following the process of (i) a preliminary screening; (ii) a systematic MEDLINE/PubMed database search; (iii) title, abstract and full-text screening; (iv) data extraction and charting. Cathelicidin levels were shown to be altered in all clinical settings investigated; its pleiotropic function was confirmed. It was found that cathelicidin contributes to maintaining homeostasis and participates in lung injury response and repair, in addition to exerting a positive effect against microbial load and infections. In addition, LL-37 was found to sustain continuous inflammation, increase mucus formation and inhibit microorganisms and corticosteroids. In addition, studies investigated cathelicidin as a treatment modality, such as cathelicidin inhalation in experimental HP, which had positive effects. However, the primary focus of the included articles was on LL-37’s antibacterial effect, leading to the conclusion that the beneficial LL-37 activity has not been adequately examined and that further research is required.
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DOI：
10.1164/rccm.200811-1757st
发表时间：
2010-09-01
影响因子：
24.7
作者：
Eisner, Mark D.;Anthonisen, Nicholas;Balmes, John R.
通讯作者：
Balmes, John R.
影响因子：
--
作者：
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通讯作者：
Monick, Martha M.
DOI：
10.1073/pnas.93.10.5156
发表时间：
1996-05-14
影响因子：
11.1
作者：
Diamond, G;Russell, JP;Bevins, CL
通讯作者：
Bevins, CL
影响因子：
--
作者：
Golec, M.;Lemieszek, M. K.;Dutkiewicz, J.
通讯作者：
Dutkiewicz, J.
影响因子：
4.8
作者：
Chen, Keqiang;Liu, Mingyong;Wang, Ji Ming
通讯作者：
Wang, Ji Ming