Differential Effects of MicroRNAs on Glioblastoma Growth and Migration.
Differential Effects of MicroRNAs on Glioblastoma Growth and Migration.
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DOI：
10.3390/genes4010046
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发表时间：
2013-03-04
期刊：
影响因子：
3.5
通讯作者：
Peruzzi F
中科院分区：
文献类型：
--
作者：
Jeansonne D;Pacifici M;Lassak A;Reiss K;Russo G;Zabaleta J;Peruzzi F
Glioblastoma multiforme is characterized by rapid proliferation, aggressive metastatic potential, and resistance to radio- and chemotherapy. The matricellular protein CYR61 regulates cellular proliferation and migration and is highly expressed in Glioblastomas. MicroRNAs are 22-nucleotides long RNAs that regulate gene expression post-transcriptionally. Here, we utilized the LN229 glioblastoma cell line and found that CYR61 is a target of miR-136, miR-155, and miR-634. Over-expression of miR-136 and miR-634 miRNAs negatively affected proliferation, but not migration, while expression of miR-155 reduced migration but did not affect the proliferation of LN229 cells. Investigation of the molecular mechanisms affected by expression of miR-634 revealed an increased phosphorylation of p70S6 kinase, suggesting an induction of the mammalian target of rapamycin (mTOR) complex 1 pathway. Additionally, in miR-634 overexpressing cells, TSC2, a negative regulator of mTOR signaling, was found to be decreased. Altogether, our study provides insights on the differential roles of miRs-136, -155, and -634 in regulating glioblastoma cell growth and migration, and how microRNAs could be manipulated to decrease the aggressiveness and metastatic potential of tumor cells.
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影响因子：
5.1
作者：
Hummel, Richard;Maurer, Jessica;Haier, Joerg
通讯作者：
Haier, Joerg
DOI：
10.1073/pnas.95.11.6355
发表时间：
1998-05-26
影响因子：
11.1
作者：
Babic, AM;Kireeva, ML;Lau, LF
通讯作者：
Lau, LF
影响因子：
3
作者：
Grabacka, M;Placha, W;Slominski, A
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Slominski, A
影响因子：
3.8
作者：
Bostner, Josefine;Karlsson, Elin;Pandiyan, Muneeswaran J.;Westman, Hanna;Skoog, Lambert;Fornander, Tommy;Nordenskjold, Bo;Stal, Olle
通讯作者：
Stal, Olle
影响因子：
20.1
作者：
Lee, Hae-Young;Chung, Jae-Woong;Kim, Hyo-Soo
通讯作者：
Kim, Hyo-Soo