Leukemia and benzene.
Leukemia and benzene.
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DOI：
10.3390/ijerph9082875
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发表时间：
2012-08
影响因子：
--
通讯作者：
Snyder R
中科院分区：
文献类型：
--
作者：
Snyder R
一个多世纪以来，人们一直知道过度接触苯会损害骨髓，导致循环血细胞数量减少，最终导致再生障碍性贫血。最近，人们认识到，接触苯的另一种结果是发展成一种或多种类型的白血病。虽然许多研究人员同意，肝脏或骨髓中产生的一系列有毒代谢物可能会导致创伤性骨髓损伤，但导致白血病的更微妙的机制尚未得到严格的剖析。这一问题似乎引起了更广泛的关注，因为人们认识到，由于先前用烷化剂治疗肿瘤缓解而导致的所谓“第二癌症”，通常会导致一种让人想起苯诱导的白血病的类型。此外，有越来越多的文献试图描述骨髓的精细结构，并鉴定包含各种干细胞和其他类型细胞的所谓“壁龛”。其中一些“壁龛”可能含有能够引发白血病的细胞。通过细胞间和细胞内信号对干细胞分化和增殖的控制将最终决定这些转化干细胞的命运。这些细胞避开检查点的能力将阻止它们促进白血病反应，这是另一个需要研究的领域。关于苯引起的骨髓损伤的大部分研究都集中在确定哪些苯代谢物会导致白血病。现在的重点应该是了解苯代谢物是如何改变骨髓细胞生物学的。
Excessive exposure to benzene has been known for more than a century to damage the bone marrow resulting in decreases in the numbers of circulating blood cells, and ultimately, aplastic anemia. Of more recent vintage has been the appreciation that an alternative outcome of benzene exposure has been the development of one or more types of leukemia. While many investigators agree that the array of toxic metabolites, generated in the liver or in the bone marrow, can lead to traumatic bone marrow injury, the more subtle mechanisms leading to leukemia have yet to be critically dissected. This problem appears to have more general interest because of the recognition that so-called “second cancer” that results from prior treatment with alkylating agents to yield tumor remissions, often results in a type of leukemia reminiscent of benzene-induced leukemia. Furthermore, there is a growing literature attempting to characterize the fine structure of the marrow and the identification of so called “niches” that house a variety of stem cells and other types of cells. Some of these “niches” may harbor cells capable of initiating leukemias. The control of stem cell differentiation and proliferation via both inter- and intra-cellular signaling will ultimately determine the fate of these transformed stem cells. The ability of these cells to avoid checkpoints that would prevent them from contributing to the leukemogenic response is an additional area for study. Much of the study of benzene-induced bone marrow damage has concentrated on determining which of the benzene metabolites lead to leukemogenesis. The emphasis now should be directed to understanding how benzene metabolites alter bone marrow cell biology.
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影响因子：
3.1
作者：
Falconer, EH
通讯作者：
Falconer, EH
影响因子：
10.4
作者：
Hutt, AM;Kalf, GF
通讯作者：
Kalf, GF
DOI：
10.1021/i360035a014
发表时间：
1970-01-01
期刊：
INDUSTRIAL & ENGINEERING CHEMISTRY PRODUCT RESEARCH AND DEVELOPMENT
影响因子：
--
作者：
BATCHELDER, HR
通讯作者：
BATCHELDER, HR
影响因子：
20.3
作者：
AKSOY, M;ERDEM, S;DINCOL, G
通讯作者：
DINCOL, G
DOI：
10.1038/icb.1966.28
发表时间：
1966-01-01
期刊：
AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE
影响因子：
--
作者：
BRADLEY, TR;METCALF, D
通讯作者：
METCALF, D