Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states.
Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states.
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杏仁核，纹状体和皮质的刺神经元使用树突状平台潜力来检测网络状态。
DOI：
10.3389/fncel.2014.00292
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发表时间：
2014
影响因子：
5.3
通讯作者：
Antic SD
中科院分区：
文献类型：
--
作者：
Oikonomou KD;Singh MB;Sterjanaj EV;Antic SD
杏仁核、纹状体和大脑皮层的棘状神经元共有四个有趣的特征：（1）它们是各自大脑区域内最丰富的细胞类型，（2）被数千个多刺突起（树突棘）覆盖，（3）具有高水平的树突状NMDA电导，（4）在体内和体外经历持续的躯体去极化（UP状态）。在前脑的所有多刺神经元中，足够的突触能输入产生树突平台电位（“树突UP状态”），其特征在于（i）快速上升，（ii）持续几百毫秒的平台期，和（iii）在平台期结束时突然下降。树突平台电位逐渐向细胞体传播，以诱导持久（长于100 ms，最常见的是200-800 ms）的稳定去极化（幅度<20 mV），这类似于神经元UP状态。基于电压敏感染料成像，索马中的平台去极化精确地时间锁定到树突中发生的再生平台电位。躯体平台上升后的树突状电压瞬变和崩溃的树突状平台去极化的击穿。我们假设，神经元UP状态在体内反映了树突平台电位（树突UP状态）的发生。我们建议，在神经元UP状态的体细胞电压波形是由树突平台电位。哺乳动物棘状神经元使用树突平台电位来检测相干网络活动并将其转化为普遍存在的神经元UP状态。树突平台电位的生物物理特性允许神经元快速调谐到正在进行的网络活动，以及确保连续UP状态的稳定振幅。
Spiny neurons of amygdala, striatum, and cerebral cortex share four interesting features: (1) they are the most abundant cell type within their respective brain area, (2) covered by thousands of thorny protrusions (dendritic spines), (3) possess high levels of dendritic NMDA conductances, and (4) experience sustained somatic depolarizations in vivo and in vitro (UP states). In all spiny neurons of the forebrain, adequate glutamatergic inputs generate dendritic plateau potentials (“dendritic UP states”) characterized by (i) fast rise, (ii) plateau phase lasting several hundred milliseconds, and (iii) abrupt decline at the end of the plateau phase. The dendritic plateau potential propagates toward the cell body decrementally to induce a long-lasting (longer than 100 ms, most often 200–800 ms) steady depolarization (∼20 mV amplitude), which resembles a neuronal UP state. Based on voltage-sensitive dye imaging, the plateau depolarization in the soma is precisely time-locked to the regenerative plateau potential taking place in the dendrite. The somatic plateau rises after the onset of the dendritic voltage transient and collapses with the breakdown of the dendritic plateau depolarization. We hypothesize that neuronal UP states in vivo reflect the occurrence of dendritic plateau potentials (dendritic UP states). We propose that the somatic voltage waveform during a neuronal UP state is determined by dendritic plateau potentials. A mammalian spiny neuron uses dendritic plateau potentials to detect and transform coherent network activity into a ubiquitous neuronal UP state. The biophysical properties of dendritic plateau potentials allow neurons to quickly attune to the ongoing network activity, as well as secure the stable amplitudes of successive UP states.
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影响因子：
2.5
作者：
Compte, A;Sanchez-Vives, MV;Wang, XJ
通讯作者：
Wang, XJ
DOI：
10.1073/pnas.1317667111
发表时间：
2014-03-18
影响因子：
11.1
作者：
Brandalise, Federico;Gerber, Urs
通讯作者：
Gerber, Urs
影响因子：
4.2
作者：
Antic SD;Zhou WL;Moore AR;Short SM;Ikonomu KD
通讯作者：
Ikonomu KD
影响因子：
6.7
作者：
Buzsáki G;Silva FL
通讯作者：
Silva FL
影响因子：
2.5
作者：
Brecht, M;Singer, W;Engel, AK
通讯作者：
Engel, AK