Humanized Mouse Models for the Advancement of Innate Lymphoid Cell-Based Cancer Immunotherapies.
Humanized Mouse Models for the Advancement of Innate Lymphoid Cell-Based Cancer Immunotherapies.
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DOI：
10.3389/fimmu.2021.648580
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发表时间：
2021
影响因子：
7.3
通讯作者：
Sunwoo JB
中科院分区：
文献类型：
--
作者：
Horowitz NB;Mohammad I;Moreno-Nieves UY;Koliesnik I;Tran Q;Sunwoo JB
先天性淋巴样细胞（inate lymphoid cells，ILC）是免疫系统的一个分支，由多种循环和组织驻留细胞组成，其执行包括稳态和抗肿瘤免疫的功能。人类自然杀伤（NK）细胞和其他ILC在癌症背景下的发展和行为仍然不完全清楚。由于NK细胞和第1组和第2组ILC对于介导抗肿瘤免疫应答非常重要，因此更清楚地了解这些过程对于改善癌症治疗和整体理解肿瘤免疫学至关重要。不幸的是，人类和小鼠之间的ILC分化和效应子功能途径存在一些重大差异。为此，携带患者来源的异种移植物或人细胞系来源的肿瘤以及人基因或人免疫细胞的小鼠代表了用于在体内研究这些途径的极好工具。人源化小鼠的最新进展使人们对复杂的肿瘤-ILC相互作用有了前所未有的了解。在这篇综述中，我们讨论了ILC行为的背景下，癌症，人源化的小鼠模型，最常用的癌症研究和优化研究ILC，目前的方法来操纵人类ILC的抗肿瘤活性，和相对效用的各种小鼠模型的发展和评估这些ILC相关的免疫疗法。
Innate lymphoid cells (ILCs) are a branch of the immune system that consists of diverse circulating and tissue-resident cells, which carry out functions including homeostasis and antitumor immunity. The development and behavior of human natural killer (NK) cells and other ILCs in the context of cancer is still incompletely understood. Since NK cells and Group 1 and 2 ILCs are known to be important for mediating antitumor immune responses, a clearer understanding of these processes is critical for improving cancer treatments and understanding tumor immunology as a whole. Unfortunately, there are some major differences in ILC differentiation and effector function pathways between humans and mice. To this end, mice bearing patient-derived xenografts or human cell line-derived tumors alongside human genes or human immune cells represent an excellent tool for studying these pathways in vivo. Recent advancements in humanized mice enable unparalleled insights into complex tumor-ILC interactions. In this review, we discuss ILC behavior in the context of cancer, the humanized mouse models that are most commonly employed in cancer research and their optimization for studying ILCs, current approaches to manipulating human ILCs for antitumor activity, and the relative utility of various mouse models for the development and assessment of these ILC-related immunotherapies.
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影响因子：
30.5
作者：
Cortez VS;Ulland TK;Cervantes-Barragan L;Bando JK;Robinette ML;Wang Q;White AJ;Gilfillan S;Cella M;Colonna M
通讯作者：
Colonna M
影响因子：
32.4
作者：
Colonna M
通讯作者：
Colonna M
影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
2
作者：
Chao, Celia;Widen, Steve G.;Hellmich, Mark R.
通讯作者：
Hellmich, Mark R.
影响因子：
30.5
作者：
Bernink, Jochem H.;Peters, Charlotte P.;Spits, Hergen
通讯作者：
Spits, Hergen