Extramotor damage is associated with cognition in primary lateral sclerosis patients.
Extramotor damage is associated with cognition in primary lateral sclerosis patients.
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DOI：
10.1371/journal.pone.0082017
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Filippi M
中科院分区：
文献类型：
--
作者：
Canu E;Agosta F;Galantucci S;Chiò A;Riva N;Silani V;Falini A;Comi G;Filippi M
这是一项横断面研究，旨在调查原发性侧索硬化症（PLS）患者的认知表现，并使用扩散张量（DT）磁共振成像（MRI）来确定有或无认知缺陷患者的微结构白色物质（WM）损伤的地形分布。DT MRI扫描从21例PLS患者和35名年龄和性别匹配的健康对照组中获得。所有PLS患者进行了全面的神经心理电池。使用基于束的空间统计（TBSS）对各向异性分数（FA）、轴向、径向（radD）和平均扩散率（MD）进行全脑体素分析。10例PLS患者在至少一项神经心理学测试（PLS伴认知缺陷，PLS-cd）中得分异常。与健康对照组和认知功能正常的PLS患者（PLS-cu）相比，PLS-cd患者双侧皮质脊髓束（CST）、胼胝体、脑干、内囊前肢、上级和下纵束、穹窿、丘脑放射和顶叶的FA降低，MD和radD增加。与健康对照组相比，PLS-cd患者双侧小脑WM的FA进一步降低，radD增加。与对照组相比，PLS-cu患者的胼胝体中部FA减少。在PLS中，执行和语言测试成绩与WM损伤相关。这是第一个评估PLS患者认知能力和WM束损伤之间关系的研究。PLS可能与多领域认知障碍相关。大脑半球间、边缘系统和主要关联性WM束的WM损害似乎是这些患者认知异常的结构相关性。
This is a cross-sectional study aimed at investigating cognitive performances in patients with primary lateral sclerosis (PLS) and using diffusion tensor (DT) magnetic resonance imaging (MRI) to determine the topographical distribution of microstructural white matter (WM) damage in patients with or without cognitive deficits. DT MRI scans were obtained from 21 PLS patients and 35 age- and sex-matched healthy controls. All PLS patients underwent a comprehensive neuropsychological battery. Tract-based-spatial-statistics (TBSS) was used to perform a whole-brain voxel-wise analysis of fractional anisotropy (FA), axial, radial (radD) and mean diffusivity (MD). Ten PLS patients had abnormal scores in at least one neuropsychological test (PLS with cognitive deficits, PLS-cd). Compared with healthy controls and cognitively unimpaired PLS patients (PLS-cu), PLS-cd cases showed decreased FA and increased MD and radD in the corticospinal tract (CST), corpus callosum, brainstem, anterior limb of internal capsule, superior and inferior longitudinal fasciculi, fornix, thalamic radiations, and parietal lobes, bilaterally. Compared with healthy controls, PLS-cd patients showed further decreased FA and increased radD in the cerebellar WM, bilaterally. Compared with controls, PLS-cu patients showed decreased FA in the mid-body of corpus callosum. In PLS, executive and language test scores correlated with WM damage. This is the first study evaluating the relationship between cognitive performance and WM tract damage in PLS patients. PLS can be associated with a multi-domain cognitive impairment. WM damage to interhemispheric, limbic and major associative WM tracts seem to be the structural correlate of cognitive abnormalities in these patients.
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影响因子：
3.3
作者：
Della Sala, S;MacPherson, SE;Spinnler, H
通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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