Public Health Importance of Invasive Methicillin-sensitive Staphylococcus aureus Infections: Surveillance in 8 US Counties, 2016.
Public Health Importance of Invasive Methicillin-sensitive Staphylococcus aureus Infections: Surveillance in 8 US Counties, 2016.
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DOI：
10.1093/cid/ciz323
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发表时间：
2020-03-03
期刊：
影响因子：
--
通讯作者：
See I
中科院分区：
文献类型：
--
作者：
Jackson KA;Gokhale RH;Nadle J;Ray SM;Dumyati G;Schaffner W;Ham DC;Magill SS;Lynfield R;See I
美国的公共卫生和感染控制预防和监测工作主要集中在耐甲氧西林金黄色葡萄球菌（MRSA）。我们描述了公共卫生的重要性，甲氧西林敏感的S。金黄色葡萄球菌（MSSA）在选定的社区。我们分析了新发感染项目对侵袭性链球菌的监测数据。金黄色葡萄球菌（SA）感染（从正常无菌的身体部位分离），2016年在5个州的8个县。如果在入院后>3天获得培养物;如果与透析、住院、手术或长期护理机构（LTCF）居住相关，则认为病例与医疗保健相关;或者如果中心静脉导管存在≤2天。计算每10万人口的发病率，并采用随机截距的多变量logistic回归模型比较MSSA和MRSA的危险因素。侵袭性MSSA发生率（31.3/100 000）是MRSA（17.5/100 000）的1.8倍。与MRSA患者相比，MSSA患者更可能没有基础疾病（调整后的比值比[aOR]，2.06; 95%置信区间[CI]，1.26-3.39），既往住院（aOR，0.70; 95% CI，0.60-0.82）或LTCF居住（aOR，0.37; 95% CI，0.29-0.47）的可能性更小。MSSA占卫生保健相关病例的59.7%和死亡的60.1%。虽然MRSA往往与医疗暴露更密切相关，但侵袭性MSSA是研究地区的一个重大公共卫生问题。除了MRSA之外，公共卫生和感染控制预防工作还应考虑MSSA预防。
Public health and infection control prevention and surveillance efforts in the United States have primarily focused on methicillin-resistant Staphylococcus aureus (MRSA). We describe the public health importance of methicillin-susceptible S. aureus (MSSA) in selected communities. We analyzed Emerging Infections Program surveillance data for invasive S. aureus (SA) infections (isolated from a normally sterile body site) in 8 counties in 5 states during 2016. Cases were considered healthcare-associated if culture was obtained >3 days after hospital admission; if associated with dialysis, hospitalization, surgery, or long-term care facility (LTCF) residence within 1 year prior; or if a central venous catheter was present ≤2 days prior. Incidence per 100 000 census population was calculated, and a multivariate logistic regression model with random intercepts was used to compare MSSA risk factors with those of MRSA. Invasive MSSA incidence (31.3/100 000) was 1.8 times higher than MRSA (17.5/100 000). Persons with MSSA were more likely than those with MRSA to have no underlying medical conditions (adjusted odds ratio [aOR], 2.06; 95% confidence interval [CI], 1.26–3.39) and less likely to have prior hospitalization (aOR, 0.70; 95% CI, 0.60–0.82) or LTCF residence (aOR, 0.37; 95% CI, 0.29–0.47). MSSA accounted for 59.7% of healthcare-associated cases and 60.1% of deaths. Although MRSA tended to be more closely associated with healthcare exposures, invasive MSSA is a substantial public health problem in the areas studied. Public health and infection control prevention efforts should consider MSSA prevention in addition to MRSA.
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影响因子：
3.7
作者：
David MZ;Boyle-Vavra S;Zychowski DL;Daum RS
通讯作者：
Daum RS
影响因子：
4.5
作者：
Calfee, David P.;Salgado, Cassandra D.;Yokoe, Deborah S.
通讯作者：
Yokoe, Deborah S.
影响因子：
3.2
作者：
Hsiang, Michelle S.;Shiau, Rita;Pan, Erica
通讯作者：
Pan, Erica
影响因子：
11.8
作者：
Liu, Catherine;Bayer, Arnold;Chambers, Henry F.
通讯作者：
Chambers, Henry F.
影响因子：
11.8
作者：
Cosgrove, SE;Sakoulas, G;Carmeli, Y
通讯作者：
Carmeli, Y