High Signal Intensity on Diffusion-Weighted Images Reflects Acute Phase of Deep Vein Thrombus.
High Signal Intensity on Diffusion-Weighted Images Reflects Acute Phase of Deep Vein Thrombus.
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DOI：
10.1055/s-0040-1714280
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发表时间：
2020-10
影响因子：
6.7
通讯作者：
Asada Y
中科院分区：
文献类型：
--
作者：
Gi T;Kuroiwa Y;Yamashita A;Mizutani Y;Asanuma T;Miyati T;Maekawa K;Aman M;Imamura T;Asada Y
抗血栓治疗对深静脉血栓形成（DVT）的影响可能受到血栓年龄的影响，而非侵入性成像方式无法可靠地确定血栓年龄。我们研究了磁共振（MR）弥散加权成像（DWI）是否可以在DVT患者、动物模型和体外人血中定位和确定静脉血栓的年龄。应用1.5T磁共振成像系统对8例DVT患者的DWI信号强度（SI）和血栓的表观扩散系数（ADC）进行了测定。我们使用3.0 T MRI系统评估了随时间推移在兔颈静脉中形成静脉血栓的组织化过程。我们还使用1.5-T MRI系统评估了体外人体血液的MRI信号。所有患者的静脉血栓均通过DWI检测为高或混合高和等SI区域。血栓近端ADC值低于远端ADC值。兔颈静脉血栓的组织学结构呈时间依赖性，DWI上4小时为高SI，1周和2周为高SI和等SI混合，3周为等SI。ADC值与红细胞含量呈负相关，与平滑肌细胞、巨噬细胞、含铁血黄素、胶原含量呈正相关。体外人血的MRI信号显示ADC受红细胞含量的影响，但不受凝血的影响。磁共振弥散加权成像可检测静脉血栓，弥散加权成像高SI伴低ADC值可能反映富含红细胞的急性期血栓。
The effects of antithrombotic therapy on deep vein thrombosis (DVT) can be affected by thrombus age, which cannot be reliably determined by noninvasive imaging modalities. We investigated whether magnetic resonance (MR) diffusion-weighted imaging (DWI) can localize and determine the age of venous thrombus in patients with DVT, animal models, and human blood in vitro. Signal intensity (SI) on DWI and the apparent diffusion coefficient (ADC) of thrombi were assessed in eight patients with DVT using a 1.5-T MR imaging (MRI) system. We assessed the organizing processes as venous thrombus developed in the rabbit jugular vein using a 3.0-T MRI system over time. We also assessed MRI signals of human blood in vitro using the 1.5-T MRI system. Venous thrombi were detected by DWI as areas of high or mixed high and iso SI in all patients. The ADCs were lower in the proximal, than in the distal portion of the thrombi. The thrombi of rabbit jugular veins histologically organized in a time-dependent manner, with high SI on DWI at 4 hours, mixed high and iso SI at 1 and 2 weeks, and iso SI at 3 weeks. The ADC correlated negatively with erythrocyte content, and positively with smooth muscle cells, macrophages, hemosiderin, and collagen content. MRI signals of human blood in vitro showed that ADCs were affected by erythrocyte content, but not by blood clotting. MR-DWI can detect venous thrombus, and high SI on DWI accompanied by a low ADC might reflect erythrocyte-rich, acute-phase thrombi.
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DOI：
10.1055/s-0039-1678683
发表时间：
2019-01-01
期刊：
TH open : companion journal to thrombosis and haemostasis
影响因子：
--
作者：
Dronkers, Charlotte E A;Klok, Frederikus A;Kroft, Lucia J M
通讯作者：
Kroft, Lucia J M
影响因子：
3.1
作者：
Furukoji E;Gi T;Yamashita A;Moriguchi-Goto S;Kojima M;Sugita C;Sakae T;Sato Y;Hirai T;Asada Y
通讯作者：
Asada Y
影响因子：
39.2
作者：
Fraser, DGW;Moody, AR;Davidson, I
通讯作者：
Davidson, I
影响因子：
2.6
作者：
Ichiki, M.;Sakai, Y.;Miki, Y.
通讯作者：
Miki, Y.
影响因子：
4.3
作者：
Yamaki, Takashi;Nozaki, Motohiro;Kim, Kaya
通讯作者：
Kim, Kaya