Wastewater-Based Epidemiology (WBE) and Viral Detection in Polluted Surface Water: A Valuable Tool for COVID-19 Surveillance-A Brief Review.
Wastewater-Based Epidemiology (WBE) and Viral Detection in Polluted Surface Water: A Valuable Tool for COVID-19 Surveillance-A Brief Review.
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DOI：
10.3390/ijerph17249251
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发表时间：
2020-12-10
影响因子：
--
通讯作者：
Siqueira MM
中科院分区：
文献类型：
--
作者：
Aguiar-Oliveira ML;Campos A;R Matos A;Rigotto C;Sotero-Martins A;Teixeira PFP;Siqueira MM
SARS-CoV-2是当前COVID-19大流行的病原体。疾病临床表现从无症状到严重的多器官损害。SARS-CoV-2使用ACE 2作为细胞受体，其在小肠中大量表达，允许病毒在胃肠道中复制。在COVID-19患者的粪便中检测到病毒RNA，并在其中一些样本中分离出活病毒。因此，SARS-CoV-2粪-口传播的假定作用一直存在争议。SARS-CoV-2在人类排泄物中脱落，并在基本卫生条件差的环境中被进一步丢弃在下水道或环境中。基于水的流行病学（WBE）是一种有价值的监测病毒病原体的人群水平的方法，并已成功地用于不同的情况。本文综述了目前全球不同大陆SARS-CoV-2 WBE和污染地表水中病毒检测的经验。讨论了该策略用于SARS-CoV-2监测的优势和问题。结果表明，WBE是一个有价值的预警警报和有益的补充监测工具，以平息公共卫生反应，量身定制的遏制和缓解措施，并确定测试的目标人群。在卫生条件差的环境中，受污染的河流也可作为环境监测的一个来源。
SARS-CoV-2 is the causative agent of the current COVID-19 pandemic. Disease clinical manifestations range from asymptomatic to severe multiple organ damage. SARS-CoV-2 uses ACE2 as a cellular receptor, which is abundantly expressed in the small intestine, allowing viral replication in the gastrointestinal tract. Viral RNA has been detected in the stool of COVID-19 patients and viable viruses had been isolated in some of these samples. Thus, a putative role of SARS-CoV-2 fecal-oral transmission has been argued. SARS-CoV-2 is shed in human excreta and further disposed in the sewerage or in the environment, in poor basic sanitation settings. Wastewater-based epidemiology (WBE) is a valuable population level approach for monitoring viral pathogens and has been successfully used in different contexts. This review summarizes the current global experience on SARS-CoV-2 WBE in distinct continents and viral detection in polluted surface water. The advantages and concerns of this strategy for SARS-CoV-2 surveillance are discussed. Outcomes suggest that WBE is a valuable early warning alert and a helpful complementary surveillance tool to subside public health response, to tailor containment and mitigation measures and to determine target populations for testing. In poor sanitation settings, contaminated rivers could be alternatively used as a source for environmental surveillance.
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影响因子：
8.9
作者：
Carraturo, Federica;Del Giudice, Carmela;Guida, Marco
通讯作者：
Guida, Marco
DOI：
10.1016/j.coesh.2020.01.006
发表时间：
2020-08-01
影响因子：
--
作者：
Bofill-Mas, Silvia;Rusinol, Marta
通讯作者：
Rusinol, Marta
DOI：
10.1016/j.scitotenv.2020.142575
发表时间：
2021-02-10
期刊：
The Science of the total environment
影响因子：
--
作者：
Elsamadony M;Fujii M;Miura T;Watanabe T
通讯作者：
Watanabe T
影响因子：
9.8
作者：
Adelodun, Bashir;Ajibade, Fidelis Odedishemi;Choi, Kyung-Sook
通讯作者：
Choi, Kyung-Sook
影响因子：
12.8
作者：
D'Aoust PM;Mercier E;Montpetit D;Jia JJ;Alexandrov I;Neault N;Baig AT;Mayne J;Zhang X;Alain T;Langlois MA;Servos MR;MacKenzie M;Figeys D;MacKenzie AE;Graber TE;Delatolla R
通讯作者：
Delatolla R