Influenza Transmission in Preschools: Modulation by contact landscapes and interventions.

Influenza Transmission in Preschools: Modulation by contact landscapes and interventions.
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DOI:
10.1051/mmnp/20105301
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发表时间:
2010-01-01
影响因子:
2.2
通讯作者:
Hotchkiss JR
Hotchkiss JR
中科院分区:
数学4区
文献类型:
--
作者:
Adalja AA;Crooke PS;Hotchkiss JR

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流行病学数据表明,学校和日托设施可能在流感传播中发挥主要作用。病原体在如此小的、不均匀混合的人群中的传播很难使用传统方法进行建模。我们开发了基于模拟的数学工具,以研究在类似于日托中心或小学的环境中,社会接触网络对病原体传播的影响。在这里,我们表明,减少儿童保育设施内的混合,包括限制社会集群的大小,减少社会集群之间的接触频率,并消除大型聚会的干预措施,可以减少病原体的传播。此外,这些措施可能会扩大疫苗接种或抗病毒预防的有效性,即使疫苗不是一致有效或抗病毒依从性不完全。类似的考虑也适用于其他小的、不完全混合的人群,如办公室和学校。
Epidemiologic data suggest that schools and daycare facilities likely play a major role in the dissemination of influenza. Pathogen transmission within such small, inhomogenously mixed populations is difficult to model using traditional approaches. We developed simulation based mathematical tool to investigate the effects of social contact networks on pathogen dissemination in a setting analogous to a daycare center or grade school. Here we show that interventions that decrease mixing within child care facilities, including limiting the size of social clusters, reducing the contact frequency between social clusters, and eliminating large gatherings, could diminish pathogen dissemination. Moreover, these measures may amplify the effectiveness of vaccination or antiviral prophylaxis, even if the vaccine is not uniformly effective or antiviral compliance is incomplete. Similar considerations should apply to other small, imperfectly mixed populations, such as offices and schools.
将网络理论应用于流行病:肺炎支原体暴发的控制措施。
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