Ameliorating effects of auricular electroacupuncture on rectal distention-induced gastric dysrhythmias in rats.
Ameliorating effects of auricular electroacupuncture on rectal distention-induced gastric dysrhythmias in rats.
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DOI：
10.1371/journal.pone.0114226
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Chen JD
中科院分区：
文献类型：
--
作者：
Zhang Z;Yin J;Chen JD
胃慢波（GSW）被认为是调节胃运动的，并且随着直肠扩张（RD）而受损。电针（EA）在身体穴位，如ST 36，已被证明可以改善胃节律障碍，然而，很少有人知道耳穴电针（AEA）对GSW的可能影响。为探讨AEA对RD诱导的大鼠胃节律紊乱的影响及其可能机制，对10只SD大鼠在进食状态下进行了两个不同的实验。实验1分为对照组（RD组）、RD+AEA组、RD+电针组和RD+假AEA组。实验2分为两个阶段：RD +阿托品和RD +阿托品+ AEA，研究AEA的作用机制。结果表明：（1）RD使正常胃黏膜损伤率由89.8±3.5%降至76.0±3.3% AEA使RD时正常GSW的百分比增加到94.0±2.1%（P<0.05 vs. RD）通过降低胃动过速和心律失常的百分比阿托品可阻断AEA对RD所致胃电节律紊乱的改善作用。我们的研究结果表明，RD诱导大鼠在进食状态下的胃节律紊乱。AEA通过迷走神经通路改善RD诱导的胃节律紊乱。AEA可能对胃节律紊乱具有治疗潜力。
Gastric slow waves (GSW) are known to regulate gastric motility and are impaired with rectal distention (RD). Electroacupuncture (EA) at body acupoints, such as ST 36, has been shown to improve gastric dysrhythmias; however, little is known about the possible effects of auricular electroacupuncture (AEA) on GSW. To study effects and possible mechanisms of AEA on RD-induced gastric dysrhythmias in rats, ten male Sprague-Dawley (SD) rats implanted with gastric serosal electrodes were studied in two different experiments in fed state. Four sessions were performed in experiment 1 as follows: control (RD, no stimulation), RD+AEA, RD+EA at body points and RD+sham AEA. Two sessions were included in experiment 2 to study mechanisms of AEA: RD + atropine and RD + atropine + AEA. It was found that 1) RD significantly decreased the percentage of normal GSW from 89.8±3.5% to 76.0±3.3% (P<0.05); 2) AEA increased the percentage of normal GSW during RD to 94.0±2.1% (P<0.05 vs. RD) via a reduction in the percentages of tachygastria and arrhythmia (P<0.05 vs. RD); 3) atropine blocked the ameliorating effect of AEA on RD-induced gastric dysrhythmias. Our results demonstrated that RD induces gastric dysrhythmias in fed state in rats. AEA improves RD-induced gastric dysrhythmias via the vagal pathway. AEA may have a therapeutic potential in treating gastric dysrhythmias.
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DOI：
10.1093/ecam/nem106
发表时间：
2007-09
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
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影响因子：
2.6
作者：
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影响因子：
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DOI：
10.1023/a:1016333109829
发表时间：
2002-09-01
期刊：
Cardiac electrophysiology review
影响因子：
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作者：
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