Hippocampal size predicts rapid learning of a cognitive map in humans.
Hippocampal size predicts rapid learning of a cognitive map in humans.
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DOI：
10.1002/hipo.22111
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发表时间：
2013-06
期刊：
影响因子：
3.5
通讯作者：
Epstein, Russell A.
中科院分区：
文献类型：
--
作者：
Schinazi, Victor R.;Nardi, Daniele;Newcombe, Nora S.;Shipley, Thomas F.;Epstein, Russell A.
人类使用灵活的地图式环境表示来指导空间导航的想法有着悠久而有争议的历史。这场持久争论的一个原因可能是，个体在形成和利用认知地图的能力上存在很大差异。在这里，我们调查这些个体差异的行为和神经解剖学特征。参与者在三周的时间里学习了一个陌生的校园环境。在他们的第一次访问中，他们了解了校园不同区域沿着两条路线上不同建筑物的位置。在接下来的几周里，他们第二次和第三次学习了这些路线，沿着两条连接校园两个区域的路径。每次学习后的行为评估表明，受试者形成了一个连贯的表示空间结构的整个校园后，学习一个单一的连接path.Volume分析的结构MRI数据和体素为基础的形态学（VBM）表明，右后海马体的大小预测的能力，使用这种空间知识，使推断校园内不同建筑物的相对位置。在尾状核中观察到灰质体积和性能之间的反比关系。这些结果表明，（i）人类可以快速获得大规模环境的认知地图，（ii）海马解剖结构的个体差异可能为学习和灵活使用这些认知地图的能力的个体差异提供神经解剖学基础。
The idea that humans use flexible map-like representations of their environment to guide spatial navigation has a long and controversial history. One reason for this enduring controversy might be that individuals vary considerably in their ability to form and utilize cognitive maps. Here we investigate the behavioral and neuroanatomical signatures of these individual differences. Participants learned an unfamiliar campus environment over a period of three weeks. In their first visit, they learned the position of different buildings along two routes in separate areas of the campus. During the following weeks, they learned these routes for a second and third time, along with two paths that connected both areas of the campus. Behavioral assessments after each learning session indicated that subjects formed a coherent representation of spatial structure of the entire campus after learning a single connecting path. Volumetric analyses of structural MRI data and voxel-based morphometry (VBM) indicated that the size of the right posterior hippocampus predicted the ability to use this spatial knowledge to make inferences about the relative positions of different buildings on the campus. An inverse relationship between gray matter volume and performance was observed in the caudate. These results suggest that (i) humans can rapidly acquire cognitive maps of large-scale environments and (ii) individual differences in hippocampal anatomy may provide the neuroanatomical substrate for individual differences in the ability to learn and flexibly use these cognitive maps.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1523/jneurosci.4549-07.2007
发表时间：
2007-12-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hassabis D;Kumaran D;Maguire EA
通讯作者：
Maguire EA
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
19.9
作者：
Epstein, Russell A.
通讯作者：
Epstein, Russell A.
DOI：
10.3758/bf03204960
发表时间：
1987-05-01
期刊：
ANIMAL LEARNING & BEHAVIOR
影响因子：
--
作者：
CHAPUIS, N;DURUP, M;THINUSBLANC, C
通讯作者：
THINUSBLANC, C