Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence.
Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence.
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早期生活中严峻的家庭气候预示着青春期促炎表型的出现。
DOI：
10.1177/0956797610370161
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发表时间：
2010-06
影响因子：
8.2
通讯作者：
Chen E
中科院分区：
文献类型：
--
作者：
Miller GE;Chen E
越来越多的证据表明，在严酷的家庭中长大的儿童在以后的生活中容易患慢性病和过早死亡。为了阐明这一现象潜在的机制，我们评估了这样一个假设，即这种家族会产生促炎表型，其特点是细胞因子对细菌刺激的反应夸大，并对皮质醇的抗炎特性产生抵抗。在一年半的时间里，对135名青春期女性的样本进行了四次评估，反复测量心理压力和炎症活动。在一定程度上，他们是在严酷的家庭中长大的，在随访中，参与者表现出越来越多的促炎表型。这表现为对体外细菌挑战的细胞因子反应日益明显，糖皮质激素受体逐渐脱敏，这阻碍了皮质醇适当调节炎症反应的能力。如果持续下去，这些倾向可能会让来自危险家庭的孩子走上老龄化的慢性疾病的轨道。
Mounting evidence indicates that children who are reared in harsh families are prone to chronic diseases and premature mortality later in life. To shed light on the mechanisms potentially underlying this phenomenon, we evaluated the hypothesis that such families engender a pro-inflammatory phenotype, marked by exaggerated cytokine responses to bacterial stimuli and resistance to the anti-inflammatory properties of cortisol. A sample of 135 adolescent females were assessed four times over 1.5 years, with repeated measurements of psychological stress and inflammatory activity. To the extent that they were reared in harsh families, participants displayed an increasingly pro-inflammatory phenotype over the follow-up. This was marked by increasingly pronounced cytokine responses to in vitro bacterial challenge, and a progressive desensitization of the glucocorticoid receptor, which hampered cortisol’s ability to properly regulate inflammatory responses. If sustained, these tendencies may place children from risky families on a trajectory for the chronic diseases of aging.
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影响因子：
10.6
作者：
Miller, Andrew H.;Maletic, Vladimir;Raison, Charles L.
通讯作者：
Raison, Charles L.
影响因子：
3.3
作者：
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通讯作者：
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Matthews, KA
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作者：
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通讯作者：
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