Notch and bone morphogenetic protein differentially act on dermomyotome cells to generate endothelium, smooth, and striated muscle.
Notch and bone morphogenetic protein differentially act on dermomyotome cells to generate endothelium, smooth, and striated muscle.
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缺口和骨形态发生蛋白差异作用于皮肤肌细胞，从而产生内皮，光滑和横纹的肌肉。
DOI：
10.1083/jcb.200707206
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发表时间：
2008-02-11
影响因子：
7.8
通讯作者：
Kalcheim, Chaya
中科院分区：
文献类型：
--
作者：
Ben-Yair, Raz;Kalcheim, Chaya
我们探讨了骨骼肌、平滑肌和内皮细胞在真皮肌节中从上皮祖细胞生成的机制。谱系分析表明，在所有上皮结构域中，外侧区是平滑肌和内皮最多产的区域。重要的是，单个标记的侧体节细胞只产生内皮细胞或壁细胞（而不是两者），内皮细胞和壁细胞的分化是由不同的信号系统驱动的。Notch活性是平滑肌产生所必需的，同时抑制横纹肌分化，但它不影响内皮细胞的初始发育。另一方面，骨形态发生蛋白信号传导是内皮细胞分化和/或迁移所需的，但抑制横纹肌分化，并不能影响平滑肌细胞的产生。因此，尽管平滑肌和内皮生成的机制不同，但平滑肌与横纹肌的选择取决于单一的信号系统。总之，这些研究结果强调了在一个明显同质的上皮细胞谱系多样化的空间和时间的复杂性。
We address the mechanisms underlying generation of skeletal muscle, smooth muscle, and endothelium from epithelial progenitors in the dermomyotome. Lineage analysis shows that of all epithelial domains, the lateral region is the most prolific producer of smooth muscle and endothelium. Importantly, individual labeled lateral somitic cells give rise to only endothelial or mural cells (not both), and endothelial and mural cell differentiation is driven by distinct signaling systems. Notch activity is necessary for smooth muscle production while inhibiting striated muscle differentiation, yet it does not affect initial development of endothelial cells. On the other hand, bone morphogenetic protein signaling is required for endothelial cell differentiation and/or migration but inhibits striated muscle differentiation and fails to impact smooth muscle cell production. Hence, although different mechanisms are responsible for smooth muscle and endothelium generation, the choice to become smooth versus striated muscle depends on a single signaling system. Altogether, these findings underscore the spatial and temporal complexity of lineage diversification in an apparently homogeneous epithelium.
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