The Future Application of Organ-on-a-Chip Technologies as Proving Grounds for MicroBioRobots.
The Future Application of Organ-on-a-Chip Technologies as Proving Grounds for MicroBioRobots.
复制标题
未来有机芯片技术作为微生物机器人的验证基础。
DOI：
10.3390/mi11100947
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发表时间：
2020-10-20
期刊：
影响因子：
3.4
通讯作者：
Ruder WC
中科院分区：
文献类型：
--
作者：
Fuller HC;Wei TY;Behrens MR;Ruder WC
对疾病发病机制的不断理解迫使开发新的药物递送方法。最近，生物启发的微型机器人作为药物输送系统获得了牵引力。通过利用生理系统中发现的微尺度现象，这些微型机器人可以被设计成具有更大的可操作性，从而实现更精确、受控的药物释放。作为其开发的一部分，可以通过在生理相关模型系统中测试其功效来进一步改善其功能。随着微型机器人的出现，器官芯片技术在药物发现和生理建模中变得重要。这些系统在微流体设备中再现器官水平的功能，并且还可以结合疾病的特定生物、化学和物理方面。本文综述了微机器人和器官芯片技术的最新发展，并展望了它们在开发未来药物输送系统中的联合应用。
An evolving understanding of disease pathogenesis has compelled the development of new drug delivery approaches. Recently, bioinspired microrobots have gained traction as drug delivery systems. By leveraging the microscale phenomena found in physiological systems, these microrobots can be designed with greater maneuverability, which enables more precise, controlled drug release. Their function could be further improved by testing their efficacy in physiologically relevant model systems as part of their development. In parallel with the emergence of microscale robots, organ-on-a-chip technologies have become important in drug discovery and physiological modeling. These systems reproduce organ-level functions in microfluidic devices, and can also incorporate specific biological, chemical, and physical aspects of a disease. This review highlights recent developments in both microrobotics and organ-on-a-chip technologies and envisions their combined use for developing future drug delivery systems.
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影响因子：
14
作者：
Gold K;Gaharwar AK;Jain A
通讯作者：
Jain A
DOI：
10.1177/1535370214532596
发表时间：
2014-09
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Clark AM;Wheeler SE;Taylor DP;Pillai VC;Young CL;Prantil-Baun R;Nguyen T;Stolz DB;Borenstein JT;Lauffenburger DA;Venkataramanan R;Griffith LG;Wells A
通讯作者：
Wells A
影响因子：
2.5
作者：
Chen, Ping;Cui, Bin;Wang, Yaoyu
通讯作者：
Wang, Yaoyu
影响因子：
3.7
作者：
Farahat, Waleed A.;Wood, Levi B.;Asada, H. Harry
通讯作者：
Asada, H. Harry
影响因子：
24
作者：
Humbert, M;Morrell, NW;Rabinovitch, M
通讯作者：
Rabinovitch, M