The modulation of pancreatic lipase activity by alginates.
The modulation of pancreatic lipase activity by alginates.
复制标题
DOI：
10.1016/j.foodchem.2013.09.075
复制
发表时间：
2014-03-01
期刊：
影响因子：
8.8
通讯作者：
Pearson, Jeffrey P.
中科院分区：
文献类型：
--
作者：
Wilcox, Matthew D.;Brownlee, Iain A.;Richardson, J. Craig;Dettmar, Peter W.;Pearson, Jeffrey P.
某些藻酸盐是胰脂肪酶的有效抑制剂。藻酸盐对脂肪酶的抑制程度与聚合物的结构有关。高古洛糖醛酸藻酸盐比高甘露糖醛酸盐实现更大的脂肪酶抑制。藻酸盐有可能成为一种耐受性良好的肥胖治疗方法。藻酸盐由甘露糖醛酸（M）和古洛糖醛酸（G）组成，并且已经显示出抑制酶活性。胰脂肪酶在膳食三酰甘油分解中是重要的;降低胰脂肪酶活性将减少三酰甘油分解，导致被身体吸收的量降低。在生物聚合物存在下的脂肪酶活性通过使用天然和合成底物的酶测定来评估。海藻酸钠对合成底物（DGGR）和天然底物胰脂肪酶的抑制率分别为72.2%（± 4.1）和58.0%（± 9.7）。高G海藻酸盐从海带hyperborea海藻抑制胰脂肪酶的显着更高的程度比高M海藻酸盐从Lessonia nigrescens，显示抑制相关的海藻酸盐结构。高G藻酸盐是胰脂肪酶的有效抑制剂，并以低水平用于食品工业。它们可以在不改变感官品质的情况下以更高的水平包含在食物中，可能减少膳食三酰甘油的摄入，有助于体重管理。
Certain alginates are effective inhibitors of pancreatic lipase. The level of lipase inhibition by alginates is related to the structure of the polymer. High guluronate alginates achieve greater lipase inhibition than high mannuronate. Alginates have the potential to be a well-tolerated obesity treatment. Alginates are comprised of mannuronic (M) and guluronic acid (G) and have been shown to inhibit enzyme activity. Pancreatic lipase is important in dietary triacylglycerol breakdown; reducing pancreatic lipase activity would reduce triacylglycerol breakdown resulting in lower amounts being absorbed by the body. Lipase activity in the presence of biopolymers was assessed by enzymatic assay using natural and synthetic substrates. Alginate inhibited pancreatic lipase by a maximum of 72.2% (±4.1) with synthetic substrate (DGGR) and 58.0% (±9.7) with natural substrate. High-G alginates from Laminaria hyperborea seaweed inhibited pancreatic lipase to a significantly higher degree than High-M alginates from Lessonia nigrescens, showing that inhibition was related to alginate structure. High-G alginates are effective inhibitors of pancreatic lipase and are used in the food industry at low levels. They could be included at higher levels in foods without altering organoleptic qualities, potentially reduce the uptake of dietary triacylglycerol aiding in weight management.
登录
查看更多内容
DOI：
10.1016/0005-2760(88)90260-3
发表时间：
1988-10-14
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BORGSTROM, B
通讯作者：
BORGSTROM, B
影响因子：
5.8
作者：
Jemel, Kram;Fendri, Ahmed;Bezzine, Sofiane
通讯作者：
Bezzine, Sofiane
影响因子：
5.8
作者：
Strugala, V;Kennington, EJ;Dettmar, PW
通讯作者：
Dettmar, PW
影响因子：
6.2
作者：
Taylor, C;Draget, KI;Smidsrod, O
通讯作者：
Smidsrod, O
影响因子：
6.5
作者：
Tsujita, Takahiro;Takaichi, Hiroe;Hiraki, Jun
通讯作者：
Hiraki, Jun