Post-weaning social isolation causes sex-specific alterations to dendritic spine density in subregions of the prefrontal cortex and nucleus accumbens of adult mice.
Post-weaning social isolation causes sex-specific alterations to dendritic spine density in subregions of the prefrontal cortex and nucleus accumbens of adult mice.
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DOI：
10.1016/j.brainres.2021.147755
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发表时间：
2022-02-15
期刊：
影响因子：
2.9
通讯作者：
Briand LA
中科院分区：
文献类型：
--
作者：
McGrath AG;Briand LA
断奶后的社会隔离压力已被证明会增加成年后的成瘾行为。这些长期的行为改变可能是由于长时间的隔离引起的大脑区域中参与奖励处理的神经元的结构变化。先前的研究表明，各种压力源会改变前额叶皮层（PFC）和脑桥核的树突棘密度，尽管这些研究中的许多研究都是针对压力的短期影响，并且主要在男性中进行。越来越多的证据表明，男性和女性在应激反应方面表现出差异，一些研究表明，在应激诱导的可塑性方面存在性别差异。为了确定断奶后社会隔离后脊柱密度的长期、性别特异性变化，在断奶时将雄性和雌性小鼠隔离或分组饲养，并在它们成年后测量脊柱密度。断奶后的隔离增加了脊柱密度PFC的男性和女性，虽然在边缘下皮层的影响更明显的女性。在神经核，青少年隔离增加脊柱密度的男性只有在核心和外壳。女性也有更高的基线棘密度比男性的核神经节的核心。这些数据表明，青少年的社会隔离会导致前额叶皮层和丘脑核的长期、性别特异性的改变。
Post-weaning social isolation stress has been shown to increase addiction-like behavior in adulthood. These long-term behavioral alterations may be due to long lasting isolation-induced structural changes to neurons in brain regions involved in reward processing. Previous studies have shown that various stressors alter dendritic spine density in the prefrontal cortex (PFC) and the nucleus accumbens, though many of these studies examine the short-term effects of stress, and are primarily conducted in males. There is mounting evidence that males and females exhibit differences in their stress responses, with some studies showing sex differences in stress-induced plasticity. To determine the long-lasting, sex-specific alterations in spine density following post-weaning social isolation, male and female mice were either isolated or group housed at weaning and spine density was measured once they reached adulthood. Post-weaning isolation increased spine density in the PFC of both the males and females, although the effects in the infralimbic cortex were more pronounced in the females. In the nucleus accumbens, adolescent isolation increased spine density in males only in the core and shell. Females also had higher baseline spine density than males in the nucleus accumbens core. Together these data suggest that adolescent social isolation causes long-term, sex-specific alterations to the prefrontal cortex and the nucleus accumbens.
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影响因子：
16.2
作者：
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通讯作者：
Nedivi E
影响因子：
3.3
作者：
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作者：
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3
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影响因子：
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作者：
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通讯作者：
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