Altered Behavior in Mice Socially Isolated During Adolescence Corresponds With Immature Dendritic Spine Morphology and Impaired Plasticity in the Prefrontal Cortex.
Altered Behavior in Mice Socially Isolated During Adolescence Corresponds With Immature Dendritic Spine Morphology and Impaired Plasticity in the Prefrontal Cortex.
复制标题
DOI：
10.3389/fnbeh.2018.00087
复制
发表时间：
2018
影响因子：
3
通讯作者：
Jenrow KA
中科院分区：
文献类型：
--
作者：
Medendorp WE;Petersen ED;Pal A;Wagner LM;Myers AR;Hochgeschwender U;Jenrow KA
青春期被社会孤立的小鼠表现出焦虑、抑郁和社交互动受损的行为。尽管这些行为有据可查，但人们对伴随这些行为的相关神经生物学变化知之甚少。根据在隔离小鼠和前额皮质结构破坏的小鼠中观察到的类似行为异常，有人假设青春期的社会隔离会改变前额叶皮层的发育。为了建立行为与前额皮质潜在神经生物学变化之间的关系，将 Thy-1-GFP 小鼠从断奶直至成年进行分离，并与群养的同窝小鼠的行为、电生理活动和树突形态进行比较。结果表明，单养动物的树突棘不成熟，树突棘显得更小、更薄。通过长期增强的测量，单舍小鼠还表现出可塑性受损。这些发现共同表明，这些动物行为特征背后的前额叶皮层发育发生了改变，并受到了损害。
Mice socially isolated during adolescence exhibit behaviors of anxiety, depression and impaired social interaction. Although these behaviors are well documented, very little is known about the associated neurobiological changes that accompany these behaviors. It has been hypothesized that social isolation during adolescence alters the development of the prefrontal cortex, based on similar behavioral abnormalities observed in isolated mice and those with disruption of this structure. To establish relationships between behavior and underlying neurobiological changes in the prefrontal cortex, Thy-1-GFP mice were isolated from weaning until adulthood and compared to group-housed littermates regarding behavior, electrophysiological activity and dendritic morphology. Results indicate an immaturity of dendritic spines in single housed animals, with dendritic spines appearing smaller and thinner. Single housed mice additionally show impaired plasticity through measures of long-term potentiation. Together these findings suggest an altered development and impairment of the prefrontal cortex of these animals underlying their behavioral characteristics.
登录
查看更多内容
影响因子：
5.7
作者：
Ackman JB;Crair MC
通讯作者：
Crair MC
DOI：
10.1016/j.bbagen.2015.09.009
发表时间：
2015-12-01
影响因子：
3
作者：
Amiri, Shayan;Amini-Khoei, Hossein;Hosseini, Mir-Jamal
通讯作者：
Hosseini, Mir-Jamal
影响因子：
2.5
作者：
CASSELL, MD;CHITTICK, CA;WRIGHT, DJ
通讯作者：
WRIGHT, DJ
影响因子：
3.4
作者：
Browne, Caleb J.;Fletcher, Paul J.;Zeeb, Fiona D.
通讯作者：
Zeeb, Fiona D.
少年仓鼠的社交发挥改变了内侧前额叶皮层中的树突形态，并减轻了成年后社会压力的影响。
影响因子：
1.9
作者：
Burleson CA;Pedersen RW;Seddighi S;DeBusk LE;Burghardt GM;Cooper MA
通讯作者：
Cooper MA