Quail egg homogenate alleviates food allergy induced eosinophilic esophagitis like disease through modulating PAR-2 transduction pathway in peanut sensitized mice.
Quail egg homogenate alleviates food allergy induced eosinophilic esophagitis like disease through modulating PAR-2 transduction pathway in peanut sensitized mice.
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鹌鹑蛋匀浆通过调节花生致敏小鼠的 PAR-2 转导途径减轻食物过敏引起的嗜酸性食管炎样疾病
DOI：
10.1038/s41598-018-19309-x
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发表时间：
2018-01-18
影响因子：
4.6
通讯作者：
Che H
中科院分区：
文献类型：
--
作者：
Lianto P;Han S;Li X;Ogutu FO;Zhang Y;Fan Z;Che H
目前治疗嗜酸性粒细胞性食管炎（EoE）的药物主要依靠吸入糖皮质激素。尽管口服局部类固醇可以成功地限制EoE相关炎症，但长期使用类固醇仍存在问题，特别是在儿童中。在目前的研究中，我们评估了鹌鹑蛋，据报道，这是一种已知的丝氨酸蛋白酶抑制剂，对花生致敏的食物过敏诱导的EoE小鼠模型的免疫学和免疫应答的影响。每日口服鹌鹑蛋可降低小鼠的生殖学和免疫应答。鹌鹑蛋治疗抑制抗原引起的小鼠类胰蛋白酶和嗜酸性粒细胞阳离子蛋白（ECP）的血清和嗜酸性粒细胞的炎症组织，如食管，肺和消化系统中的增量。鹌鹑蛋处理导致EoE中抗体特异性IgE和IgG 1以及异常表达的多种炎症基因的减少。其他作用包括炎症组织中IL-10增加、PAR-2活化和NF-κ B p65降低。我们的研究结果表明，鹌鹑蛋治疗可能具有治疗潜力，通过调节PAR-2下游通路，通过阻断转录因子NF-κ B p65活性的激活，减轻食物过敏诱导的EoE样疾病的症状。
The present pharmacotherapy for eosinophilic esophagitis (EoE) fundamentally depend on inhaled corticosteroids. Despite the fact that oral intake of topical steroids can be successful in restricting EoE-related inflammation, there are concerns with respect to the long term utilization of steroids, especially in kids. In the current research, we assess the effect of quail egg, which is reportedly a known serine protease inhibitor, on symptomatology and immune responses in a peanut-sensitized mouse model of food allergy induced EoE. Daily oral treatment with quail egg attenuated mice symptomatology and immune response. Treatment with quail egg inhibited antigen-prompted increments in mouse tryptase and eosinophil cationic protein (ECP) in serum and eosinophil in inflamed tissues like oesophagus, lung, and digestive system. Quail egg treatment resulted in decreased antibody specific IgE and IgG1 and a variety of inflammatory genes that were abnormally expressed in EoE. Other effects included increased IL-10, decreased PAR-2 activation and NF-kB p65 in inflamed tissues. Our results suggest that quail egg treatment may have therapeutic potential in attenuating the symptoms of food allergy induced EoE like disease through regulating PAR-2 downstream pathway by blocking the activation of the transcription factor NF-kB p65 activity.
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影响因子：
16.8
作者：
Levi-Schaffer, F;Piliponsky, AM
通讯作者：
Piliponsky, AM
影响因子：
5.6
作者：
Cho JY;Rosenthal P;Miller M;Pham A;Aceves S;Sakuda S;Broide DH
通讯作者：
Broide DH
影响因子：
3.9
作者：
Benichou, Annie-Claude;Armanet, Marion;Bussiere, Anthony;Chevreau, Nathalie;Cardot, Jean-Michel;Tetard, Jan
通讯作者：
Tetard, Jan
影响因子：
14.2
作者：
Abonia, J. Pablo;Blanchard, Carine;Butz, Bridget Buckmeier;Rainey, Heather F.;Collins, Margaret H.;Stringer, Keith;Putnam, Philip E.;Rothenberg, Marc E.
通讯作者：
Rothenberg, Marc E.
影响因子：
10.3
作者：
Hashimoto, Y;Arai, I;Nakaike, S
通讯作者：
Nakaike, S