Resveratrol for Alzheimer's disease.
Resveratrol for Alzheimer's disease.
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DOI：
10.1111/nyas.13431
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发表时间：
2017-09
影响因子：
5.2
通讯作者：
Turner RS
中科院分区：
文献类型：
--
作者：
Sawda C;Moussa C;Turner RS
淀粉样蛋白假说认为，随着年龄的增长，中枢神经系统淀粉样蛋白的进行性积累和沉积是阿尔茨海默病（AD）的近因。因此，靶向衰老的分子机制可能是一种可行的治疗方法。在动物模型中，热量限制可能通过激活sirtuins来预防衰老疾病，包括AD。sirtuins（如哺乳动物SIRT 1）是将能量平衡（NAD+/NADH）与基因转录调控联系起来的脱乙酰酶。白藜芦醇是SIRT 1的有效激活剂，因此可以模仿热量限制来预防衰老疾病。我们进行了一项随机、双盲、安慰剂对照的白藜芦醇治疗轻度至中度AD患者的II期临床试验。白藜芦醇（1）在脑脊液中可检测到（低纳摩尔水平），（2）安全且耐受性良好，（3）改变AD生物标志物轨迹，（4）保持血脑屏障完整性，（5）调节CNS免疫反应。需要进一步的研究来确定白藜芦醇的安全性和有效性，以及这种方法在治疗和预防AD和其他衰老疾病中的有效性。
The amyloid hypothesis suggests that the progressive accumulation and deposition of central nervous system amyloid with aging is the proximate cause of Alzheimer’s disease (AD). Thus, targeting molecular mechanisms of aging may represent a viable treatment approach. Caloric restriction prevents diseases of aging, including AD, in animal models, perhaps by activation of sirtuins. The sirtuins (such as mammalian SIRT1) are deacetylases that link energy balance (NAD+/NADH) to regulation of gene transcription. Resveratrol is a potent activator of SIRT1, and thus may mimic caloric restriction to prevent diseases of aging. We conducted a randomized, double blind, placebo-controlled, phase II trial of resveratrol for individuals with mild to moderate AD. Resveratrol (1) is detectable in cerebrospinal fluid (at low nanomolar levels), (2) is safe and well tolerated, (3) alters AD biomarker trajectories, (4) preserves blood–brain barrier integrity, and (5) modulates the CNS immune response. Further studies are needed to determine the safety and efficacy of resveratrol and the validity of this approach in the treatment and prevention of AD and other diseases of aging.
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影响因子：
11.2
作者：
FRATIGLIONI, L;AHLBOM, A;WINBLAD, B
通讯作者：
WINBLAD, B
DOI：
10.1523/jneurosci.5657-12.2013
发表时间：
2013-05-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gräff J;Kahn M;Samiei A;Gao J;Ota KT;Rei D;Tsai LH
通讯作者：
Tsai LH
影响因子：
9.9
作者：
Hebert, L. E.;Bienias, J. L.;Evans, D. A.
通讯作者：
Evans, D. A.
影响因子：
15.9
作者：
Dubois, B;Masure, S;Arnold, B
通讯作者：
Arnold, B
影响因子：
3.5
作者：
Hussain, I;Powell, D;Christie, G
通讯作者：
Christie, G