Particulate matter and Alzheimer's disease: an intimate connection.
Particulate matter and Alzheimer's disease: an intimate connection.
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DOI：
10.1016/j.molmed.2022.06.004
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发表时间：
2022-09
影响因子：
13.6
通讯作者：
Wold, Loren E.
中科院分区：
文献类型：
--
作者：
O'Piela, Devin R.;Durisek III, George R.;Escobar, Yael-Natalie H.;Mackos, Amy R.;Wold, Loren E.
几十年来，人们一直认识到环境在疾病进展中的作用。然而，对空气中有毒物质暴露如何影响肺部以外的器官的理解是一个未被充分认识的科学探究领域。颗粒物 (PM) 包括各种气体、液体和悬浮颗粒，由化石燃料燃烧等工业活动以及野火和火山爆发等自然事件产生。尽管各机构试图降低可接受的空气颗粒物水平，但随着城市化和人口增长，这些政策在减缓疾病进展方面仅起到了一定的作用。越来越多的研究领域关注 PM 暴露在阿尔茨海默病进展中的作用。这篇评论将总结这个不断扩展的领域的已知和未知。
The environmental role in disease progression has been appreciated for decades; however, the understanding of how airborne toxicant exposure can affect organs beyond the lungs is an underappreciated area of scientific inquiry. Particulate matter (PM) includes various gases, liquids, and particles in suspension and is produced by industrial activities such as fossil fuel combustion and natural events including wildfires and volcanic eruptions. Although agencies have attempted to reduce acceptable airborne particulate levels, with urbanization and population growth, these policies have been only moderately effective in mitigating disease progression. A growing area of research is focused on the role of PM exposure in the progression of Alzheimer’s disease. This review will summarize the knowns and unknowns of this expanding field.
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影响因子：
6.8
作者：
Cacciottolo M;Wang X;Driscoll I;Woodward N;Saffari A;Reyes J;Serre ML;Vizuete W;Sioutas C;Morgan TE;Gatz M;Chui HC;Shumaker SA;Resnick SM;Espeland MA;Finch CE;Chen JC
通讯作者：
Chen JC
影响因子：
5
作者：
Ailshire, Jennifer A.;Crimmins, Eileen M.
通讯作者：
Crimmins, Eileen M.
影响因子：
4
作者：
Calderon-Garciduenas, Lilian;Mukherjee, Partha S.;Villanueva-Duque, Jose A.
通讯作者：
Villanueva-Duque, Jose A.
影响因子：
3.8
作者：
Brenneman, KA;Wong, BA;Dorman, DC
通讯作者：
Dorman, DC
影响因子：
5.3
作者：
Fakhoury M
通讯作者：
Fakhoury M