Disruption of persistent nociceptive behavior in rats with learning impairment.
Disruption of persistent nociceptive behavior in rats with learning impairment.
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DOI：
10.1371/journal.pone.0074533
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mao J
中科院分区：
文献类型：
--
作者：
Ma Y;Wang S;Tian Y;Chen L;Li G;Mao J
Despite the subjective nature of pain experience with cognitive and affective dimensions, preclinical pain research has largely focused on its sensory dimension. Here, we examined the relationship between learning/memory and nociceptive behavior in rats with combined learning impairment and persistent nociception. Learning impairment was induced by bilateral hippocampal injection of a mixed Aβ solution, whereas persistent nociception produced in these rats by complete Freund’s adjuvant-induced ankle inflammation. Those rats with learning impairment showed a diminished development of thermal hyperalgesia and mechanical allodynia and a shorter time course of nociceptive behavior without alteration of their baseline nociceptive threshold. In rats with pre-established hyperalgesia and allodynia due to ankle inflammation, bilateral intra-hippocampal injection of cycloheximide (a protein synthesis inhibitor) promoted the earlier recovery of nociceptive behavior. Moreover, expression of Aβ, NR1 subunit of the N-methyl-D-aspartate receptor, and protein kinase Cγ was upregulated, whereas the choline acetyl transferase expression was downregulated, in the hippocampus, thalamus, amygdala, and/or spinal cord of rats with combined learning impairment and persistent nociception. The data indicate that learning impairment could disrupt the response to a state of persistent nociception, suggesting an important role for cognitive maladaptation in the mechanisms of chronic pain. These results also suggest that a preclinical model of combined learning impairment and persistent nociception may be useful to explore the brain mechanisms underlying the transition from acute to chronic pain.
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DOI：
10.1016/j.jpain.2009.06.002
发表时间：
2009-10
期刊：
The journal of pain
影响因子：
--
作者：
Mao J
通讯作者：
Mao J
影响因子：
2.9
作者：
Hernstadt H;Wang S;Lim G;Mao J
通讯作者：
Mao J
影响因子：
168.9
作者：
Ferri, CP;Prince, M;Scazufca, M
通讯作者：
Scazufca, M
影响因子：
64.8
作者：
Manabe, T;Noda, Y;Takeshima, H
通讯作者：
Takeshima, H
影响因子：
39.2
作者：
FERRELL, BA
通讯作者：
FERRELL, BA