Translational pain research: achievements and challenges.

Translational pain research: achievements and challenges.
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DOI:
10.1016/j.jpain.2009.06.002
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发表时间:
2009-10
期刊:
The journal of pain
影响因子:
--
通讯作者:
Mao J
Mao J
中科院分区:
其他
文献类型:
--
作者:
Mao J

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在过去的四十年中,临床前和临床疼痛研究的成就导致了临床疼痛管理的重大进展。然而,疼痛研究仍然面临着巨大的挑战,在治疗临床疼痛,特别是慢性疼痛方面仍然存在许多障碍。转化性疼痛研究需要涉及多个重要领域,包括a)弥合疼痛研究与临床疼痛管理之间的差距;b)开发客观的疼痛评估工具;c)分析当前疼痛机制的理论及其与临床疼痛的相关性;d)探索临床前和临床疼痛研究的新工具;e)协调基础科学家、临床研究者和疼痛医学从业者之间的研究努力。本文结合翻译疼痛研究的成就和面临的挑战,对这些问题进行了讨论。
The achievements in both preclinical and clinical pain research over the past four decades have led to significant progresses in clinical pain management. However, pain research still faces enormous challenges and there remain many obstacles in the treatment of clinical pain, particularly chronic pain. Translational pain research needs to involve a number of important areas including a) bridging the gap between pain research and clinical pain management, b) developing objective pain assessment tools, c) analyzing current theories of pain mechanisms and their relevance to clinical pain, d) exploring new tools for both preclinical and clinical pain research, and e) coordinating research efforts among basic scientists, clinical investigators, and pain medicine practitioners. These issues are discussed in this article in light of the achievements and challenges of translational pain research.
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