Distinct parafacial regions in control of breathing in adult rats.
Distinct parafacial regions in control of breathing in adult rats.
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DOI：
10.1371/journal.pone.0201485
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Feldman JL
中科院分区：
文献类型：
--
作者：
Huckstepp RTR;Cardoza KP;Henderson LE;Feldman JL
最近，基于功能差异，我们将与面神经核并列的神经元细分为两个不同的群体，面旁腹侧区和侧区，即，pFV和pFL。对这些区域的组成知之甚少，即，他们是同质的还是异质的？在这里，我们操纵他们的兴奋性在自主呼吸迷走神经氨基甲酸乙酯麻醉的成年大鼠，以进一步表征其在呼吸中的作用。在pFL中，去抑制或兴奋降低呼吸频率（f），同时增加潮气量（VT），并诱导主动呼气;相反，减少兴奋没有影响。这一结果与构成条件性呼气振荡器的pFL神经元一致，该条件性呼气振荡器由在休息时被紧张性抑制的一组功能均匀的兴奋性神经元组成。在pFV中，去抑制增加f，同时假定VT反射性降低;兴奋增加f，VT和叹气率;减少兴奋减少VT，同时假定f反射性增加。因此，pFV具有需要进一步包裹的多种功能作用。有趣的是，虽然pFV的超极化减少了正在进行的呼气活动，没有扰动pFV兴奋性诱导主动呼气。因此，虽然pFV可以影响正在进行的呼气活动，推测是由pFL产生的，但它似乎不能直接诱导主动呼气。我们的结论是，pFL包含的神经元，可以启动，调节和维持主动呼气，而pFV包含的神经元亚群，差异影响呼吸模式的各个方面，包括但不限于调制正在进行的呼气活动。
Recently, based on functional differences, we subdivided neurons juxtaposed to the facial nucleus into two distinct populations, the parafacial ventral and lateral regions, i.e., pFV and pFL. Little is known about the composition of these regions, i.e., are they homogenous or heterogeneous populations? Here, we manipulated their excitability in spontaneously breathing vagotomized urethane anesthetized adult rats to further characterize their role in breathing. In the pFL, disinhibition or excitation decreased breathing frequency (f) with a concomitant increase of tidal volume (VT), and induced active expiration; in contrast, reducing excitation had no effect. This result is congruent with pFL neurons constituting a conditional expiratory oscillator comprised of a functionally homogeneous set of excitatory neurons that are tonically suppressed at rest. In the pFV, disinhibition increased f with a presumptive reflexive decrease in VT; excitation increased f, VT and sigh rate; reducing excitation decreased VT with a presumptive reflexive increase in f. Therefore, the pFV, has multiple functional roles that require further parcellation. Interestingly, while hyperpolarization of the pFV reduces ongoing expiratory activity, no perturbation of pFV excitability induced active expiration. Thus, while the pFV can affect ongoing expiratory activity, presumably generated by the pFL, it does not appear capable of directly inducing active expiration. We conclude that the pFL contains neurons that can initiate, modulate, and sustain active expiration, whereas the pFV contains subpopulations of neurons that differentially affect various aspects of breathing pattern, including but not limited to modulation of ongoing expiratory activity.
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DOI：
10.1161/hypertensionaha.111.00860
发表时间：
2013-04
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Abbott SB;Coates MB;Stornetta RL;Guyenet PG
通讯作者：
Guyenet PG
DOI：
10.1523/jneurosci.3141-10.2010
发表时间：
2010-09-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Marina N;Abdala AP;Trapp S;Li A;Nattie EE;Hewinson J;Smith JC;Paton JF;Gourine AV
通讯作者：
Gourine AV
影响因子：
4
作者：
Cinelli, Elenia;Bongianni, Fulvia;Mutolo, Donatella
通讯作者：
Mutolo, Donatella
DOI：
10.1016/s0034-5687(00)00212-7
发表时间：
2001-02-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Nattie, E;Shi, J;Li, AH
通讯作者：
Li, AH
影响因子：
25
作者：
Mulkey, DK;Stornetta, RL;Guyenet, PG
通讯作者：
Guyenet, PG