Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network.
Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network.
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DOI：
10.1002/alz.12941
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发表时间：
2023-05
影响因子：
14
通讯作者：
Eckenhoff, Roderic G.
中科院分区：
文献类型：
--
作者：
Vasunilashorn, Sarinnapha M.;Lunardi, Nadia;Newman, John C.;Crosby, Gregory;Acker, Leah;Abel, Ted;Bhatnagar, Seema;Cunningham, Colm;de Cabo, Rafael;Dugan, Laura;Hippensteel, Joseph A.;Ishizawa, Yumiko;Lahiri, Shouri;Marcantonio, Edward R.;Xie, Zhongcong;Inouye, Sharon K.;Terrando, Niccolo;Eckenhoff, Roderic G.
谵妄是一种常见的、病态的和昂贵的综合征，作为一种危险因素和结果与阿尔茨海默病（AD）和AD相关性痴呆（ADRD）密切相关。谵妄的人类研究促进了我们对谵妄发病率和患病率、危险因素、生物标志物、结局、预防和管理的认识。然而，对谵妄神经生物学的理解仍然有限。谵妄的临床前和转化模型，虽然具有挑战性的发展，可以推进我们的谵妄神经生物学知识，并为新的预防和治疗方法的发展提供信息。我们讨论了临床前和转化动物模型在谵妄中的应用，重点是（1）对当前动物模型的回顾，（2）在动物中复制人类谵妄元素的挑战和策略，以及（3）生物流体，神经生理学和神经成像转化标记物在动物中的效用。最后，我们建议临床前和转化模型的发展和验证谵妄，在这一重要领域的提高认识的目标。
Delirium is a common, morbid, and costly syndrome that is closely linked to Alzheimer’s disease (AD) and AD-related dementias (ADRD) as a risk factor and outcome. Human studies of delirium have advanced our knowledge of delirium incidence and prevalence, risk factors, biomarkers, outcomes, prevention, and management. However, understanding of delirium neurobiology remains limited. Preclinical and translational models for delirium, while challenging to develop, could advance our knowledge of delirium neurobiology and inform the development of new prevention and treatment approaches. We discuss the use of preclinical and translational animal models in delirium, focusing on (1) a review of current animal models, (2) challenges and strategies for replicating elements of human delirium in animals, and (3) the utility of biofluid, neurophysiology, and neuroimaging translational markers in animals. We conclude with recommendations for the development and validation of preclinical and translational models for delirium, with the goal of advancing awareness in this important field.
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DOI：
10.1186/2045-5380-1-9
发表时间：
2011-11-07
期刊：
Biology of mood & anxiety disorders
影响因子：
--
作者：
Belzung C;Lemoine M
通讯作者：
Lemoine M
影响因子：
2.9
作者：
Adam, Elisabeth Hannah;Haas, Victoria;Scheller, Bertram
通讯作者：
Scheller, Bertram
影响因子：
10.6
作者：
Castner, SA;Goldman-Rakic, PS
通讯作者：
Goldman-Rakic, PS
影响因子：
4.7
作者：
Breitbart, W;Rosenfeld, B;Passik, S
通讯作者：
Passik, S
影响因子：
8.8
作者：
Ballesteros, Jesus J.;Huang, Pamela;Ishizawa, Yumiko
通讯作者：
Ishizawa, Yumiko