Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice.
Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice.
复制标题
西藏野豌豆根提取物对秀丽隐杆线虫和阿霉素诱导的成年小鼠过早衰老的抗衰老作用
DOI：
10.1155/2021/9942090
复制
发表时间：
2021
影响因子：
--
通讯作者：
Hu Z
中科院分区：
文献类型：
--
作者：
Liu W;Guan Y;Qiao S;Wang J;Bao K;Mao Z;Liao L;Moskalev A;Jiang B;Zhu J;Xia C;Li J;Hu Z
海棠(Vicatia Thibetica De Boiss)为药食同源的中草药。这是首次报道了维甲草根提取物(HLB01)对秀丽线虫(Cinehabditis Elegans)延长寿命和提高健康参数的作用。对于阿霉素诱导的成年小鼠的早衰，HLB01可中和衰老相关的生物标志物，包括P21和γH_2AX。有趣的是，HLB01能系统地促进线虫和哺乳动物细胞中胶原蛋白的表达，这可能是发挥抗衰老作用的必要因素之一。此外，HLB01还被发现是一种自由基清除剂，从而发挥抗氧化能力。HLB01的寿命延长还依赖于DAF-16和HSF-1的抗氧化和抗热应激作用。综上所述，HLB01可以通过促进胶原蛋白的表达、抗氧化能力和抗应激能力来延长线虫的寿命和健康寿命，并对抗Doxo诱导的小鼠衰老。
The roots of Vicatia thibetica de Boiss are a kind of Chinese herb with homology of medicine and food. This is the first report showing the property of the extract of Vicatia thibetica de Boiss roots (HLB01) to extend the lifespan as well as promote the healthy parameters in Caenorhabditis elegans (C. elegans). For doxorubicin- (Doxo-) induced premature aging in adult mice, HLB01 counteracted the senescence-associated biomarkers, including P21 and γH2AX. Interestingly, HLB01 promoted the expression of collagen in C. elegans and mammalian cell systemically, which might be one of the essential factors to exert the antiaging effects. In addition, HLB01 was also found as a scavenger of free radicals, thereby performing the antioxidant ability. Lifespan extension by HLB01 was also dependent on DAF-16 and HSF-1 via oxidative stress resistance and heat stress resistance. Taken together, overall data suggested that HLB01 could extend the lifespan and healthspan of C. elegans and resist Doxo-induced senescence in mice via promoting the expression of collagen, antioxidant potential, and stress resistance.
登录
查看更多内容
影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
5.2
作者：
Liu, Wenwen;Lin, Huiling;Li, Jian
通讯作者：
Li, Jian
影响因子：
6.9
作者：
Mavrogonatou, Eleni;Pratsinis, Harris;Kletsas, Dimitris
通讯作者：
Kletsas, Dimitris
影响因子：
16.6
作者：
Lin XX;Sen I;Janssens GE;Zhou X;Fonslow BR;Edgar D;Stroustrup N;Swoboda P;Yates JR 3rd;Ruvkun G;Riedel CG
通讯作者：
Riedel CG
影响因子：
64.5
作者：
Han, Bing;Sivaramakrishnan, Priya;Wang, Meng C.
通讯作者：
Wang, Meng C.