Systematic Evaluation of the Impact of Involuntary Motion in Whole Body Dynamic PET

Systematic Evaluation of the Impact of Involuntary Motion in Whole Body Dynamic PET
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全身动态 PET 中不自主运动影响的系统评估

DOI:
10.1109/nss/mic44867.2021.9875689
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发表时间:
2021
期刊:
--
影响因子:
--
通讯作者:
Biguri A
Biguri A
中科院分区:
--
文献类型:
--
作者:
Biguri A

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由于扫描时间长,动态全身(DWB)PET中可能发生患者不自主运动,这可能导致组织参数的量化不准确。为了量化对Patlak参数的影响,我们使用源自患者的运动场模拟动态数据,系统地介绍了动态扫描不同通道(帧间和帧内)的运动。将估计参数与地面实况进行比较。结果表明,即使是小的运动,误差也可能很大。如果检测到任何运动,则在定量评价DWB-PET图像时应谨慎。
Involuntary patient motion can happen in dynamic whole body (DWB) PET due to long scanning times, which may cause inaccurate quantification of tissue parameters. To quantify the impact on Patlak parameters, we simulated dynamic data using patient-derived motion fields, systematically introducing the motion at different passes of the dynamic scan, both inter and intra-frame. Estimated parameters are compared against the ground truth. Results show that errors can be large, even for small motion. Caution is advised when quantitatively evaluating DWB-PET images, if any motion has been detected.
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