Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients.
Influence of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 patients.
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DOI：
10.1371/journal.pone.0245424
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Blomberg BB
中科院分区：
文献类型：
--
作者：
Frasca D;Reidy L;Cray C;Diaz A;Romero M;Kahl K;Blomberg BB
SARS-CoV-2（严重急性呼吸系统综合征冠状病毒-2）是COVID-19（2019年冠状病毒病）的病因，对患有与炎症反应加剧和随之而来的免疫功能障碍相关的既存疾病的人来说是一个重大风险。在本文中，我们评估了肥胖（一种与慢性全身性炎症相关的疾病）对COVID-19患者血液中SARS-CoV-2特异性IgG抗体分泌的影响。我们的假设是肥胖与特异性IgG抗体的减少有关。结果证实了我们的假设，并表明SARS-CoV-2 IgG抗体与COVID-19肥胖患者的体重指数（BMI）呈负相关，正如基于肥胖对体液免疫的已知影响所预期的那样。COVID-19肥胖患者的抗体也与炎症和肺部炎症的促炎和代谢标志物的血清水平呈负相关，如SAA（血清淀粉样蛋白A蛋白），CRP（C反应蛋白）和铁蛋白，但与NEFA（非酯化脂肪酸）呈正相关。这些结果可以帮助识别对免疫功能障碍具有强预测价值的炎症特征。随后可以靶向鉴定的炎症标志物以改善肥胖个体和其他慢性炎症状况个体的体液免疫。
SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequent dysfunctional immunity. In this paper, we have evaluated the influence of obesity, a condition associated with chronic systemic inflammation, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 patients. Our hypothesis is that obesity is associated with reduced amounts of specific IgG antibodies. Results have confirmed our hypothesis and have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 obese patients, as expected based on the known influence of obesity on humoral immunity. Antibodies in COVID-19 obese patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation, such as SAA (serum amyloid A protein), CRP (C-reactive protein), and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction. Inflammatory markers identified may subsequently be targeted to improve humoral immunity in individuals with obesity and in individuals with other chronic inflammatory conditions.
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DOI：
10.1146/annurev-cellbio-011620-034148
发表时间：
2020-10-06
影响因子：
11.3
作者：
Frasca D;Diaz A;Romero M;Garcia D;Blomberg BB
通讯作者：
Blomberg BB
影响因子：
37.8
作者：
Apovian CM;Gokce N
通讯作者：
Gokce N
DOI：
10.1126/science.abc6261
发表时间：
2020-09-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arunachalam PS;Wimmers F;Mok CKP;Perera RAPM;Scott M;Hagan T;Sigal N;Feng Y;Bristow L;Tak-Yin Tsang O;Wagh D;Coller J;Pellegrini KL;Kazmin D;Alaaeddine G;Leung WS;Chan JMC;Chik TSH;Choi CYC;Huerta C;Paine McCullough M;Lv H;Anderson E;Edupuganti S;Upadhyay AA;Bosinger SE;Maecker HT;Khatri P;Rouphael N;Peiris M;Pulendran B
通讯作者：
Pulendran B
影响因子：
3.8
作者：
BALLOU, SP;LOZANSKI, G
通讯作者：
LOZANSKI, G
影响因子：
6.9
作者：
Grant, Ryan W.;Dixit, Vishwa Deep
通讯作者：
Dixit, Vishwa Deep