B Cell Immunosenescence.
B Cell Immunosenescence.
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DOI：
10.1146/annurev-cellbio-011620-034148
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发表时间：
2020-10-06
影响因子：
11.3
通讯作者：
Blomberg BB
中科院分区：
文献类型：
--
作者：
Frasca D;Diaz A;Romero M;Garcia D;Blomberg BB
先天性和适应性免疫反应随着年龄的增长而下降，导致对传染病的易感性增加，对疫苗的反应减少。老年人的疾病比年轻人更严重，对发病率、残疾和死亡率等健康结果的影响更大。衰老的特征是低级慢性炎症增加，即所谓的炎症，这代表了免疫细胞变化与许多老年典型疾病和综合征之间的联系。在这篇综述中，我们总结了目前的知识与年龄相关的免疫细胞的变化，特别强调B细胞，这是更多的炎症和对感染和疫苗的反应在老年人。我们强调了最近的研究结果的因素和途径，有助于炎症和这些如何导致功能失调的免疫反应。我们总结了最近发表的研究表明，脂肪组织，随着年龄的增长而增加的大小，有助于炎症和失调的B细胞功能。
Innate and adaptive immune responses decline with age, leading to greater susceptibility to infectious diseases and reduced responses to vaccines. Diseases are more severe in old than in young individuals and have a greater impact on health outcomes such as morbidity, disability, and mortality. Aging is characterized by increased low-grade chronic inflammation, so-called inflammaging, that represents a link between changes in immune cells and a number of diseases and syndromes typical of old age. In this review we summarize current knowledge on age-associated changes in immune cells with special emphasis on B cells, which are more inflammatory and less responsive to infections and vaccines in the elderly. We highlight recent findings on factors and pathways contributing to inflammaging and how these lead to dysfunctional immune responses. We summarize recent published studies showing that adipose tissue, which increases in size with aging, contributes to inflammaging and dysregulated B cell function.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
4
作者：
Campisi, Judith
通讯作者：
Campisi, Judith
影响因子：
3.9
作者：
Borrego, F;Alonso, MC;Solana, R
通讯作者：
Solana, R
影响因子：
39.2
作者：
AUSTRIAN, R;GOLD, J
通讯作者：
GOLD, J
影响因子：
4.4
作者：
Anspach, J;Poulsen, G;Zwollo, P
通讯作者：
Zwollo, P