A new class of fluorescent boronic acids that have extraordinarily high affinities for diols in aqueous solution at physiological pH.
A new class of fluorescent boronic acids that have extraordinarily high affinities for diols in aqueous solution at physiological pH.
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DOI：
10.1002/chem.201000637
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发表时间：
2010-12-03
影响因子：
4.3
通讯作者：
Wang, Binghe
中科院分区：
文献类型：
--
作者：
Cheng, Yunfeng;Ni, Nanting;Yang, Wenqian;Wang, Binghe
硼酸基团是传感器设计的重要识别部分。在此，我们报告了一系列异喹啉基硼酸，它们在生理 pH 下对含二醇化合物具有极高的亲和力。此外，5-和 8-异喹啉基硼酸也显示出与 d-葡萄糖相当高的结合亲和力（Ka 分别为 42 和 46 M−1）。首次发现这些硼酸与顺式环己二醇的结合较弱，但令人鼓舞。这种结合伴随着显着的荧光变化。此外，4-和6-异喹啉基硼酸还表现出络合甲基-α-d-吡喃葡萄糖的能力（Ka分别为3和2 M−1）。
The boronic acid group is an important recognition moiety for sensor design. Herein we report a series of isoquinolinylboronic acids that have extraordinarily high affinities for diol-containing compounds at physiological p H. In addition, 5- and 8-isoquinolinylboronic acids also showed fairly high binding affinities with d-glucose (Ka = 42 and 46 M−1, respectively). For the very first time, weak but encouraging binding with cis-cyclohexanediol was found for these boronic acids. Such binding was coupled with significant fluorescence changes. Furthermore, 4- and 6-isoquinolinylboronic acids also showed ability to complex methyl-α-d-glucopyranose (Ka = 3 and 2 M−1, respectively).
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影响因子：
2.7
作者：
Jin S;Zhu C;Li M;Wang B
通讯作者：
Wang B
影响因子：
13.3
作者：
Jin, Shan;Cheng, Yunfeng;Reid, Suazette;Li, Minyong;Wang, Binghe
通讯作者：
Wang, Binghe
影响因子：
3
作者：
Akay, Senol;Yang, Wenqian;Wang, Binghe
通讯作者：
Wang, Binghe
影响因子：
2.1
作者：
Liang, Xiaofen;James, Tony D.;Zhao, Jianzhang
通讯作者：
Zhao, Jianzhang
影响因子：
1.8
作者：
Luvino, Delphine;Gasparutto, Didier;Vasseur, Jean-Jacques
通讯作者：
Vasseur, Jean-Jacques