Novel Viroid-Like RNAs Naturally Infect a Filamentous Fungus.
Novel Viroid-Like RNAs Naturally Infect a Filamentous Fungus.
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新型类病毒RNA自然感染丝状真菌
DOI：
10.1002/advs.202204308
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发表时间：
2023-01
期刊：
影响因子：
15.1
通讯作者：
Xu, Wenxing
中科院分区：
文献类型：
--
作者：
Dong, Kaili;Xu, Chuan;Kotta-Loizou, Ioly;Jiang, Jingjing;Lv, Ruiying;Kong, Linghong;Li, Shifang;Hong, Ni;Wang, Guoping;Coutts, Robert H. A.;Xu, Wenxing
迄今为止，已发现类病毒仅自然感染植物，导致某些作物遭受重大损失。类病毒或类病毒 RNA 是否能自然感染非植物宿主仍不清楚。据报道，存在一组外源单链环状 RNA，大小范围为 157 至 450 个核苷酸，从真菌 Botryosphaeria dothidea 中分离出来，并命名为 B. dothidea RNA (BdcRNA)。 BdcRNA 通过遵循对称途径的滚环机制在细胞核中自主复制。 BdcRNA 感染会引起症状，因为 BdcRNA 显然可以在不同程度上调节宿主真菌的特定生物学特性（例如，改变形态、降低生长速度、减弱毒力以及增加或降低对渗透和氧化应激的耐受性）。总体而言，BdcRNA 具有与类病毒相似的基因组特征，并对真菌宿主表现出致病作用。建议将这些感染 RNA 的新型真菌称为真菌类病毒。就基因组复杂性而言，BdcRNA 可以被视为生命前沿的额外居民，代表了一类具有调节功能的新型非细胞实体和生物信息的新型表观基因组载体。一类新型类病毒 RNA，称为类病毒，自然感染丝状真菌 Botryosphaeria dothidea，导致真菌毒力和生长速度减弱。这些真菌类病毒的大小范围在 157 至 450 个核苷酸之间，通过遵循对称途径的滚环复制机制在细胞核中自主复制，并调节宿主真菌的代谢途径。
To date, viroids have been found to naturally infect only plants, resulting in substantial losses for some crops. Whether viroids or viroid‐like RNAs naturally infect non‐plant hosts remains unknown. Here the existence of a set of exogenous, single‐stranded circular RNAs, ranging in size from 157 to 450 nucleotides, isolated from the fungus Botryosphaeria dothidea and nominated B. dothidea RNAs (BdcRNAs) is reported. BdcRNAs replicate autonomously in the nucleus via a rolling‐circle mechanism following a symmetric pathway. BdcRNA infection induces symptoms, because BdcRNAs can apparently modulate, to different degrees, specific biological traits (e.g., alter morphology, decrease growth rate, attenuate virulence, and increase or decrease tolerance to osmotic and oxidative stress) of the host fungus. Overall, BdcRNAs have genome characteristics similar to those of viroids and exhibit pathogenic effects on fungal hosts. It is proposed that these novel fungus infecting RNAs should be termed mycoviroids. BdcRNA(s) may be considered additional inhabitants at the frontier of life in terms of genomic complexity, and represent a new class of acellular entities endowed with regulatory functions, and novel epigenomic carriers of biological information. A novel class of viroid‐like RNAs, termed as mycoviroids, naturally infects a filamentous fungus Botryosphaeria dothidea responsible for fungal attenuated virulence and growth rate. These mycoviroids range in size between 157 and 450 nucleotides, replicate autonomously in the nucleus via a rolling‐circle replication mechanism following symmetric pathways, and regulate the metabolic pathways of the host fungus.
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影响因子：
1.2
作者：
Machida, Satoru;Shibuya, Makoto;Sano, Teruo
通讯作者：
Sano, Teruo
影响因子：
2.9
作者：
SCHUMACHER, J;RANDLES, JW;RIESNER, D
通讯作者：
RIESNER, D
影响因子：
5.4
作者：
Delan-Forino, Clementine;Maurel, Marie-Christine;Torchet, Claire
通讯作者：
Torchet, Claire
DOI：
10.1073/pnas.85.23.9128
发表时间：
1988-12-01
影响因子：
11.1
作者：
BRANCH, AD;BENENFELD, BJ;ROBERTSON, HD
通讯作者：
ROBERTSON, HD
影响因子：
3.8
作者：
PALLAS, V;NAVARRO, A;FLORES, R
通讯作者：
FLORES, R