Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications.
Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications.
复制标题
痴呆症鉴别诊断中的淀粉样蛋白成像：审查和潜在的临床应用。
DOI：
10.1186/alzrt93
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发表时间：
2011-11-10
期刊：
影响因子：
--
通讯作者：
Rabinovici GD
中科院分区：
文献类型：
--
作者：
Laforce R Jr;Rabinovici GD
In the past decade, positron emission tomography (PET) with carbon-11-labeled Pittsburgh Compound B (PIB) has revolutionized the neuroimaging of aging and dementia by enabling in vivo detection of amyloid plaques, a core pathologic feature of Alzheimer's disease (AD). Studies suggest that PIB-PET is sensitive for AD pathology, can distinguish AD from non-AD dementia (for example, frontotemporal lobar degeneration), and can help determine whether mild cognitive impairment is due to AD. Although the short half-life of the carbon-11 radiolabel has thus far limited the use of PIB to research, a second generation of tracers labeled with fluorine-18 has made it possible for amyloid PET to enter the clinical era. In the present review, we summarize the literature on amyloid imaging in a range of neurodegenerative conditions. We focus on potential clinical applications of amyloid PET and its role in the differential diagnosis of dementia. We suggest that amyloid imaging will be particularly useful in the evaluation of mildly affected, clinically atypical or early age-at-onset patients, and illustrate this with case vignettes from our practice. We emphasize that amyloid imaging should supplement (not replace) a detailed clinical evaluation. We caution against screening asymptomatic individuals, and discuss the limited positive predictive value in older populations. Finally, we review limitations and unresolved questions related to this exciting new technique.
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影响因子：
9.9
作者：
Boxer, A. L.;Rabinovici, G. D.;Miller, B. L.
通讯作者：
Miller, B. L.
影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
2.6
作者：
Devanand DP;Mikhno A;Pelton GH;Cuasay K;Pradhaban G;Dileep Kumar JS;Upton N;Lai R;Gunn RN;Libri V;Liu X;van Heertum R;Mann JJ;Parsey RV
通讯作者：
Parsey RV
影响因子：
11
作者：
Golomb, J;Wisoff, J;Graves, W
通讯作者：
Graves, W
影响因子：
9.9
作者：
Ballard, C.;Ziabreva, I.;Aarsland, D.
通讯作者：
Aarsland, D.