Cancer stem cell marker Musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer.
Cancer stem cell marker Musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer.
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癌症干细胞标记 Musashi-1 rs2522137 基因型与肺癌风险增加相关
DOI：
10.1371/journal.pone.0095915
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Wang X;Hu JF;Tan Y;Cui J;Wang G;Mrsny RJ;Li W
基因单核苷酸多态(SNPs)已被广泛研究与多种恶性肿瘤的发生和预后有关。然而，癌症干细胞(CSC)标记基因的遗传多态与癌症风险之间的潜在作用尚未被研究。本研究采用病例对照研究的方法，共纳入东北地区中国地区的1,000名受试者(肺癌患者500例，年龄匹配的非肺癌对照500例)。用Logistic回归模型分析四个肺CSC标志物基因(CD133、ALDH1、Musashi-1和EpCAM)的基因型与肺癌风险的关系。单因素分析发现，Musashi-1 rs2522137 GG基因与TT型相比，肺癌发病率较高。未观察到CD133、ALDH1或EpCAM基因变异的显著相关性。在多变量分析中，当环境和生活方式因素纳入模型时，Musashi-1 rs2522137仍然与肺癌显著相关，这些因素包括较低的BMI、癌症家族史、既往诊断的慢性阻塞性肺病、肺炎或肺结核、职业接触杀虫剂、职业暴露于汽油或柴油、重度吸烟和暴露于严重的烹饪废气中。受试者-操作特征曲线下面积为0.7686。据我们所知，这是第一份表明武藏-1基因与肺癌风险之间存在关联的报告。此外，这项研究中的预测模型可能对确定肺癌高危人群有用。
Gene single nucleotide polymorphisms (SNPs) have been extensively studied in association with development and prognosis of various malignancies. However, the potential role of genetic polymorphisms of cancer stem cell (CSC) marker genes with respect to cancer risk has not been examined. We conducted a case-control study involving a total of 1000 subjects (500 lung cancer patients and 500 age-matched cancer-free controls) from northeastern China. Lung cancer risk was analyzed in a logistic regression model in association with genotypes of four lung CSC marker genes (CD133, ALDH1, Musashi-1, and EpCAM). Using univariate analysis, the Musashi-1 rs2522137 GG genotype was found to be associated with a higher incidence of lung cancer compared with the TT genotype. No significant associations were observed for gene variants of CD133, ALDH1, or EpCAM. In multivariate analysis, Musashi-1 rs2522137 was still significantly associated with lung cancer when environmental and lifestyle factors were incorporated in the model, including lower BMI; family history of cancer; prior diagnosis of chronic obstructive pulmonary disease, pneumonia, or pulmonary tuberculosis; occupational exposure to pesticide; occupational exposure to gasoline or diesel fuel; heavier smoking; and exposure to heavy cooking emissions. The value of the area under the receiver-operating characteristic (ROC) curve (AUC) was 0.7686. To our knowledge, this is the first report to show an association between a Musashi-1 genotype and lung cancer risk. Further, the prediction model in this study may be useful in determining individuals with high risk of lung cancer.
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影响因子：
5.7
作者：
Keysar SB;Jimeno A
通讯作者：
Jimeno A
影响因子：
3.7
作者：
Barr MP;Gray SG;Hoffmann AC;Hilger RA;Thomale J;O'Flaherty JD;Fennell DA;Richard D;O'Leary JJ;O'Byrne KJ
通讯作者：
O'Byrne KJ
DOI：
10.1083/jcb.139.5.1337
发表时间：
1997-12-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Litvinov SV;Balzar M;Winter MJ;Bakker HA;Briaire-de Bruijn IH;Prins F;Fleuren GJ;Warnaar SO
通讯作者：
Warnaar SO
影响因子：
3
作者：
Clarke, MF
通讯作者：
Clarke, MF
影响因子：
12.4
作者：
Eramo, A.;Lotti, F.;De Maria, R.
通讯作者：
De Maria, R.