Identification of inter-organ vascular network: vessels bridging between organs.
Identification of inter-organ vascular network: vessels bridging between organs.
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DOI：
10.1371/journal.pone.0065720
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Sato TN
中科院分区：
文献类型：
--
作者：
Omae M;Takada N;Yamamoto S;Nakajima H;Sato TN
器官和整个身体的发育和体内平衡严重依赖于循环系统。特别是循环系统，在各个器官之间穿梭氧气和营养物质的铁路，是器官间体液交流不可或缺的。自从世纪建立了循环系统的解剖学和力学的现代观点以来，人们一直认为体液因子是通过沿沿着体轴运行的中央动脉和静脉的血管分支运送到器官和从器官运送的。在过去的几十年里，在了解器官血管化的分子和细胞机制方面取得了重大进展。然而，关于每个器官如何通过脉管系统连接（即，器官间血管网络）。事实上，器官间血管网的确切解剖结构仍然不清楚。在此，我们报告了四个不同的血管，V1LP，V2LP，V3LP和V4LP，桥梁之间的两个器官，肝脏和胰腺发育斑马鱼的鉴定。我们发现这些器官间血管可分为两种类型：直接型和间接型。直接型血管是指通过一条不同的血管连接两个器官的血管，V1LP和V2LP血管属于直接型血管。间接型通过从茎导管发出的单独分支在两个器官之间桥接，并且V3LP和V4LP导管属于这种类型。V1LP、V2LP、V3LP和V4LP血管的发现为器官间血管网的存在提供了证据。这些和其他尚未被发现的器官间血管网络可能有助于体液因子的直接交换，这些体液因子对于所连接器官的协调生长、分化和稳态是必要的。器官间血管也可能作为其连接器官的轨道，以在其生长期间遵循，以确定其相对位置和大小差异。
Development and homeostasis of organs and whole body is critically dependent on the circulatory system. In particular, the circulatory system, the railways shuttling oxygen and nutrients among various organs, is indispensible for inter-organ humoral communication. Since the modern view of the anatomy and mechanics of the circulatory system was established in 17th century, it has been assumed that humoral factors are carried to and from organs via vascular branches of the central arteries and veins running along the body axis. Over the past few decades, major advances have been made in understanding molecular and cellular mechanisms underlying the vascularization of organs. However, very little is known about how each organ is linked by vasculature (i.e., inter-organ vascular networks). In fact, the exact anatomy of inter-organ vascular networks has remained obscure. Herein, we report the identification of four distinct vessels, V1LP, V2LP, V3LP and V4LP, that bridge between two organs, liver and pancreas in developing zebrafish. We found that these inter-organ vessels can be classified into two types: direct and indirect types. The direct type vessels are those that bridge between two organs via single distinct vessel, to which V1LP and V2LP vessels belong. The indirect type bridges between two organs via separate branches that emanate from a stem vessel, and V3LP and V4LP vessels belong to this type. Our finding of V1LP, V2LP, V3LP and V4LP vessels provides the proof of the existence of inter-organ vascular networks. These and other yet-to-be-discovered inter-organ vascular networks may facilitate the direct exchange of humoral factors that are necessary for the coordinated growth, differentiation and homeostasis of the connected organs. It is also possible that the inter-organ vessels serve as tracks for their connected organs to follow during their growth to establish their relative positions and size differences.
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影响因子：
23.9
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Butler JM;Nolan DJ;Vertes EL;Varnum-Finney B;Kobayashi H;Hooper AT;Seandel M;Shido K;White IA;Kobayashi M;Witte L;May C;Shawber C;Kimura Y;Kitajewski J;Rosenwaks Z;Bernstein ID;Rafii S
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Rafii S
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Melton, D
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Gong, Zhiyuan
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