Grey and white matter differences in Chronic Fatigue Syndrome - A voxel-based morphometry study.
Grey and white matter differences in Chronic Fatigue Syndrome - A voxel-based morphometry study.
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DOI：
10.1016/j.nicl.2017.09.024
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Blamire AM
中科院分区：
文献类型：
--
作者：
Finkelmeyer A;He J;Maclachlan L;Watson S;Gallagher P;Newton JL;Blamire AM
使用磁共振成像 (MRI) 和最新的基于体素的形态测量 (VBM) 方法研究慢性疲劳综合症 (CFS) 患者的整体和区域灰质和白质体积。使用 3-Tesla MRI 扫描仪对 42 名 CFS 患者和 30 名健康志愿者进行了扫描。解剖 MRI 扫描被分段、标准化并使用随机化方法进行 VBM 分析。在空间归一化灰质 (GM) 和白质 (WM) 片段的整体片段体积和体素方面确定了组间差异。就颅内容积而言，患者的 GM 体积较大，WM 体积较低。体素分析显示，患者组的杏仁核和岛叶等多个结构的 GM 体积增加。患者组中 WM 体积的减少主要出现在中脑、脑桥和右颞叶。 CFS 中 GM 体积升高可见于与内感受信号和压力处理相关的区域。患者组中 WM 体积的减少部分支持了中脑和脑干区域 WM 异常的早期发现。无抑郁症慢性疲劳综合征患者的 VBM 研究。患者的岛叶皮质和部分边缘系统灰质增加。患者的中脑和颞叶白质减少。研究结果表明内感受信号的处理可能发生改变。
Investigate global and regional grey and white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) and recent voxel-based morphometry (VBM) methods. Forty-two patients with CFS and thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical MRI scans were segmented, normalized and submitted to a VBM analysis using randomisation methods. Group differences were identified in overall segment volumes and voxel-wise in spatially normalized grey matter (GM) and white matter (WM) segments. Accounting for total intracranial volume, patients had larger GM volume and lower WM volume. The voxel-wise analysis showed increased GM volume in several structures including the amygdala and insula in the patient group. Reductions in WM volume in the patient group were seen primarily in the midbrain, pons and right temporal lobe. Elevated GM volume in CFS is seen in areas related to processing of interoceptive signals and stress. Reduced WM volume in the patient group partially supports earlier findings of WM abnormalities in regions of the midbrain and brainstem. VBM study of patients with Chronic Fatigue Syndrome without depression. Patients show increased grey matter in insular cortex and parts of the limbic system. Patients show decrease in white matter in midbrain and temporal lobe. Findings suggest potentially altered processing of interoceptive signals.
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影响因子：
4.3
作者：
Eccles JA;Owens AP;Mathias CJ;Umeda S;Critchley HD
通讯作者：
Critchley HD
影响因子：
2.8
作者：
Alho, Kimmo;Rinne, Teemu;Woods, David L.
通讯作者：
Woods, David L.
影响因子：
4.7
作者：
Gupta, A
通讯作者：
Gupta, A
影响因子：
2.6
作者：
Puri, B. K.;Jakeman, P. M.;Gishen, P.
通讯作者：
Gishen, P.
DOI：
10.1176/appi.neuropsych.260401
发表时间：
2014-09-01
影响因子：
2.9
作者：
Shura, Robert D.;Hurley, Robin A.;Taber, Katherine H.
通讯作者：
Taber, Katherine H.