Neural responses to morally laden interactions in female inmates with psychopathy.
Neural responses to morally laden interactions in female inmates with psychopathy.
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DOI：
10.1016/j.nicl.2021.102645
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Decety J
中科院分区：
文献类型：
--
作者：
Yoder KJ;Harenski C;Kiehl KA;Decety J
精神病人格特征不能预测女囚犯的情绪准确性。当观察有害相互作用时，PCL-R评分与dlPFC反应相关。PCL-R评分与杏仁核和TPJ中较低的功能连通性有关。许多社会认知需要对他人的精神和情绪状态做出推断。此外，理解他人的情绪是道德决策的重要基础。当观察和评价充满道德的社会互动时，精神病与异常的情绪理解和非典型的血流动力学反应有关。在目前的功能性核磁共振研究中，女囚（N = 107）被要求评估有害或有益互动的接受者或发起者可能的情绪状态。用精神病检查表-修订版（PCL-R）评估精神病。PCL-R评分与信心或准确性评分的差异无关。然而，当看到有害的相互作用时，精神病得分与右背外侧前额叶皮层的血流动力学反应增加和右杏仁核到下顶叶皮层和岛岛以及从颞顶叶连接到背内侧前额叶皮层的功能连接减少显著相关。总的来说，这项工作表明，在女性中，精神病与正常的行为准确性和信心有关，但与道德决策过程中神经网络活动的改变有关。
Psychopathic personality traits do not predict emotional accuracy in female inmates. When viewing harmful interactions, PCL-R scores are associated with dlPFC response. PCL-R scores are linked to lower functional connectivity seeded in amygdala and TPJ. Much of social cognition requires making inferences about the mental and emotional states of others. Moreover, understanding the emotions of others is an important foundation for moral decision-making. Psychopathy is associated with both aberrant emotional understanding and atypical hemodynamic responses when viewing and evaluating morally laden social interactions. In the present functional MRI study, female inmates (N = 107) were asked to evaluate the likely emotional state of either the recipient or the initiator of harmful or helpful interactions. Psychopathy was assessed with the Psychopathy Checklist-Revised (PCL-R). PCL-R scores were not associated with differences in confidence or accuracy ratings. However, psychopathy scores were significantly related to increased hemodynamic response in right dorsolateral prefrontal cortex when viewing harmful interactions and decreased functional connectivity from right amygdala to inferior parietal cortex and insula, and from temporal parietal junction to dorsomedial prefrontal cortex. Overall, this work indicates that in females, psychopathy is associated with normal behavioral accuracy and confidence but alterations in neural network activity during moral decision-making.
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