A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy.
A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy.
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DOI：
10.1039/c5sc00994d
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发表时间：
2015-10-01
期刊：
影响因子：
8.4
通讯作者：
Duan X
中科院分区：
文献类型：
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作者：
Liang R;You S;Ma L;Li C;Tian R;Wei M;Yan D;Yin M;Yang W;Evans DG;Duan X
将酞菁锌（ZnPc）和阿霉素（DOX）包封在共聚物（PVP-b-PAA-g-FA）中，制备了一种超分子纳米载体（SNV），以实现系统、靶向的肿瘤成像和治疗。将酞菁锌（ZnPc）和多柔比星（DOX）包被在共聚物（PVP-b-PAA-g-FA）中制成超分子纳米载体（SNV），从而实现系统协同化疗光动力治疗（PDT）、靶向肿瘤成像和治疗。本研究设计的复杂共聚物可以同时负载PDT光敏剂（ZnPc）和化疗药物（DOX），在HepG2细胞的体外研究和小鼠体内实验中，在化疗-PDT靶向癌症和肿瘤治疗中表现出优异的性能。本工作通过超分子材料设计提供了一种具有化疗- pdt协同作用的新药物配方，具有超低药物剂量和高效体内靶向肿瘤成像/治疗的优点。
A supramolecular nanovehicle (denoted as SNV) was fabricated by encapsulating zinc phthalocyanine (ZnPc) and doxorubicin (DOX) into a copolymer (PVP-b-PAA-g-FA), so as to achieve systematic and targeted tumor imaging and therapy. A supramolecular nanovehicle (denoted as SNV) was fabricated by encapsulating zinc phthalocyanine (ZnPc) and doxorubicin (DOX) into a copolymer (PVP-b-PAA-g-FA), so as to achieve systematic and synergistic chemotherapy-photodynamic therapy (PDT), targeted tumor imaging and therapy. The sophisticated copolymer designed in this work can load the PDT photosensitizer (ZnPc) and chemotherapy drug (DOX) simultaneously, which exhibits an excellent performance in chemotherapy-PDT targeted cancer and tumor therapy for both in vitro studies performed with HepG2 cells and in vivo tests with mice. This work provides a new drug formulation with a chemotherapy-PDT synergistic effect by virtue of the supramolecular material design, which possesses the advantages of an ultra-low drug dosage and highly-efficient in vivo targeted tumor imaging/therapy.
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影响因子：
5.6
作者：
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通讯作者：
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影响因子：
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