Gamma and beta bursts during working memory readout suggest roles in its volitional control.
Gamma and beta bursts during working memory readout suggest roles in its volitional control.
复制标题
在工作记忆读数期间，伽玛和β爆发表明了其意志控制中的作用。
DOI：
10.1038/s41467-017-02791-8
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发表时间：
2018-01-26
影响因子：
16.6
通讯作者：
Miller EK
中科院分区：
文献类型：
--
作者：
Lundqvist M;Herman P;Warden MR;Brincat SL;Miller EK
工作记忆(WM)的活动并不像之前认为的那样是静止的或持续的。有短暂的伽马(~50-120 赫兹)和贝塔(~20-35 赫兹)振荡爆发，前者与刺激性信息有关。我们研究了与WM的读出和控制机制有关的这些动力学。猴子在WM中持有两个物体的序列，以便与随后的序列匹配。贝塔和伽马爆发的变化表明它们扮演着不同的角色。由于预计将不得不使用某个对象进行匹配决策，因此有关该对象的伽马和尖峰信息增加，而贝塔爆发量减少。这种读出信号只在相关测试对象之前看到，并且与运动前活动有关。当不再需要对象时，随着对象尖峰信息的增加，贝塔增大，伽马减小。偏离这些动力学可以预测行为错误。因此，β可以调节伽马和WM中的信息。此前，作者已经证明，工作记忆可以通过短暂的伽马振荡爆发来维持。在这里，作者使用了一个新的任务来进一步演示工作记忆读数中伽马和贝塔振荡的动力学，独立于行为反应。
Working memory (WM) activity is not as stationary or sustained as previously thought. There are brief bursts of gamma (~50–120 Hz) and beta (~20–35 Hz) oscillations, the former linked to stimulus information in spiking. We examined these dynamics in relation to readout and control mechanisms of WM. Monkeys held sequences of two objects in WM to match to subsequent sequences. Changes in beta and gamma bursting suggested their distinct roles. In anticipation of having to use an object for the match decision, there was an increase in gamma and spiking information about that object and reduced beta bursting. This readout signal was only seen before relevant test objects, and was related to premotor activity. When the objects were no longer needed, beta increased and gamma decreased together with object spiking information. Deviations from these dynamics predicted behavioral errors. Thus, beta could regulate gamma and the information in WM. Previously, the authors have shown that working memory can be maintained by brief gamma oscillation bursts. Here, the authors use a new task to further demonstrate the dynamics of gamma and beta oscillations in working memory readout, independent of behavioral response.
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DOI：
10.1073/pnas.120162397
发表时间：
2000-06-20
影响因子：
11.1
作者：
Haenschel, C;Baldeweg, T;Gruzelier, J
通讯作者：
Gruzelier, J
DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
影响因子：
4.3
作者：
Lundqvist M;Compte A;Lansner A
通讯作者：
Lansner A
DOI：
10.1523/jneurosci.4075-12.2013
发表时间：
2013-01-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hussar CR;Pasternak T
通讯作者：
Pasternak T
DOI：
10.1073/pnas.1517629112
发表时间：
2015-11-03
影响因子：
11.1
作者：
Feingold, Joseph;Gibson, Daniel J.;Graybiel, Ann M.
通讯作者：
Graybiel, Ann M.