A Role for Adipocytes and Adipose Stem Cells in the Breast Tumor Microenvironment and Regenerative Medicine.
A Role for Adipocytes and Adipose Stem Cells in the Breast Tumor Microenvironment and Regenerative Medicine.
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DOI：
10.3389/fphys.2021.751239
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发表时间：
2021
影响因子：
4
通讯作者：
Burow ME
中科院分区：
文献类型：
--
作者：
Brock CK;Hebert KL;Artiles M;Wright MK;Cheng T;Windsor GO;Nguyen K;Alzoubi MS;Collins-Burow BM;Martin EC;Lau FH;Bunnell BA;Burow ME
肥胖率正在上升，是导致包括癌症在内的许多疾病的一个混杂因素和促成因素。就乳腺癌而言，肥胖在该疾病的病因学中发挥着重要作用，某些亚型（例如三阴性乳腺癌）与肥胖和不良预后之间存在很强的相关性。因此，检查正常基质和肿瘤微环境（TME）与肥胖相关的改变至关重要。脂肪细胞和脂肪干细胞（ASC）是乳腺组织基质的主要成分，在生理和病理状态下都具有重要功能，包括能量储存和代谢稳态、乳腺上皮细胞的物理支持以及通过分泌因子指导炎症和伤口愈合反应。然而，这些过程可能会在代谢紊乱（例如肥胖）和乳腺癌的情况下失调。鉴于已确立的肥胖-肿瘤轴，了解肿瘤微环境中不同细胞类型（包括脂肪细胞和 ASC）之间的相互作用如何控制癌变、肿瘤发生和最终转移至关重要。 ASC 和脂肪细胞在癌症进展中发挥多因素作用；然而，由于这些细胞的可塑性，它们在再生医学中也发挥着作用，使其成为组织工程的有希望的工具。在生理水平上，肥胖与乳腺癌之间的相互作用已得到检验；在这里，我们将描述通过癌细胞、免疫细胞和肿瘤微环境中存在的其他细胞类型之间的相互作用在这些不同环境中调节 ASC 和脂肪细胞的机制。我们将定义目前对脂肪细胞和 ASC 如何通过其在肿瘤微环境中的作用促进肿瘤进展以及在肥胖背景下如何改变这一点的理解。我们还将介绍利用脂肪细胞和 ASC 在乳房重建和再生医学新方法中的最新进展。
Obesity rates are climbing, representing a confounding and contributing factor to many disease states, including cancer. With respect to breast cancer, obesity plays a prominent role in the etiology of this disease, with certain subtypes such as triple-negative breast cancer having a strong correlation between obesity and poor outcomes. Therefore, it is critical to examine the obesity-related alterations to the normal stroma and the tumor microenvironment (TME). Adipocytes and adipose stem cells (ASCs) are major components of breast tissue stroma that have essential functions in both physiological and pathological states, including energy storage and metabolic homeostasis, physical support of breast epithelial cells, and directing inflammatory and wound healing responses through secreted factors. However, these processes can become dysregulated in both metabolic disorders, such as obesity and also in the context of breast cancer. Given the well-established obesity-neoplasia axis, it is critical to understand how interactions between different cell types in the tumor microenvironment, including adipocytes and ASCs, govern carcinogenesis, tumorigenesis, and ultimately metastasis. ASCs and adipocytes have multifactorial roles in cancer progression; however, due to the plastic nature of these cells, they also have a role in regenerative medicine, making them promising tools for tissue engineering. At the physiological level, the interactions between obesity and breast cancer have been examined; here, we will delineate the mechanisms that regulate ASCs and adipocytes in these different contexts through interactions between cancer cells, immune cells, and other cell types present in the tumor microenvironment. We will define the current state of understanding of how adipocytes and ASCs contribute to tumor progression through their role in the tumor microenvironment and how this is altered in the context of obesity. We will also introduce recent developments in utilizing adipocytes and ASCs in novel approaches to breast reconstruction and regenerative medicine.
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影响因子：
5.2
作者：
Choe SS;Huh JY;Hwang IJ;Kim JI;Kim JB
通讯作者：
Kim JB
影响因子：
5.2
作者：
Abd Elmageed, Zakaria Y.;Yang, Yijun;Thomas, Raju;Ranjan, Manish;Mondal, Debasis;Moroz, Krzysztof;Fang, Zhide;Rezk, Bashir M.;Moparty, Krishnarao;Sikka, Suresh C.;Sartor, Oliver;Abdel-Mageed, Asim B.
通讯作者：
Abdel-Mageed, Asim B.
影响因子：
14
作者：
Dunne, Lina W.;Huang, Zhao;An, Zhigiang
通讯作者：
An, Zhigiang
影响因子：
4.7
作者：
Fajka-Boja, Roberta;Szebeni, Gabor J.;Katona, Robert L.
通讯作者：
Katona, Robert L.
影响因子：
1.2
作者：
Brown, Loren M.;Hebert, Katherine L.;Lau, Frank H.
通讯作者：
Lau, Frank H.