Analysis of inflammatory mediators in type 2 diabetes patients.
Analysis of inflammatory mediators in type 2 diabetes patients.
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DOI：
10.1155/2013/976810
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发表时间：
2013
影响因子：
2.8
通讯作者：
Al-Maskari M
中科院分区：
文献类型：
--
作者：
Al-Shukaili A;Al-Ghafri S;Al-Marhoobi S;Al-Abri S;Al-Lawati J;Al-Maskari M
本研究的主要目的是通过测量一些细胞因子浓度和淋巴细胞亚群来评估 2 型糖尿病 (T2DM) 中的炎症标志物，并将其与其他实验室研究相关联。 57 名 2 型糖尿病患者和 30 名健康志愿者参与了这项研究。 C 反应蛋白 (CRP)、血红蛋白、HbA1c 和自身抗体水平的数据来自患者档案。使用市售的 ELISA 测定法测量患者血清中的细胞因子浓度。通过流式细胞术方法测量淋巴细胞亚群。与正常对照相比，T2DM 患者的 IL-1β、IL-6、IL-15 和 TNF-α 水平降低，而 IL-10、IFN-γ 和 caspase-1 水平升高。与非高血压患者相比，患有高血压的 T2DM 患者的 IL-1β 和 caspase-1 水平显着降低。病例和正常对照之间的淋巴细胞亚群没有观察到显着差异。 HbA1c 和 IL-6 之间存在显着相关性；体重指数（BMI）与CRP、TNF-α和磷酸盐显着相关；体重（Wt）与CRP和IFN-γ相关。总之，在 T2DM 患者中观察到免疫系统功能的改变。
The main aim of this study is to assess the inflammatory markers in type 2 diabetes mellitus (T2DM) by measuring some cytokines concentrations and lymphocytes subset and correlate them with other laboratory investigations. Fifty-seven patients with type-2 diabetes and 30 healthy volunteers were enrolled in this study. Data for the C-reactive protein (CRP), haemoglobin, HbA1c, and autoantibody levels were obtained from the patients files. The cytokine concentrations were measured in patient's serum using commercially available ELISA assays. Lymphocytes subsets were measured by flow cytometric methods. The levels of IL-1β, IL-6, IL-15, and TNF-α were found to be decreased in T2DM patients, whereas the levels of IL-10, IFN-γ, and caspase-1 were increased, compared to normal controls. T2DM patients with hypertension show significantly decreased levels of IL-1β and caspase-1 compared to patients without hypertension. No significant differences in lymphocytes subset between cases and normal control were observed. Significant correlations were found between HbA1c and IL-6; body mass index (BMI) was significantly correlated with CRP, TNF-α, and phosphate; the weight (Wt) was associated with CRP and IFN-γ. In conclusion, an alteration in the function of the immune system was observed in T2DM patient.
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影响因子：
7.7
作者：
Senn, JJ;Klover, PJ;Mooney, RA
通讯作者：
Mooney, RA
影响因子：
7.7
作者：
Festa, A;D'Agostino, R;Haffner, SM
通讯作者：
Haffner, SM
影响因子：
3.4
作者：
Khaodhiar, L;Ling, PR;Bistrian, BR
通讯作者：
Bistrian, BR
DOI：
10.4103/1947-2714.94944
发表时间：
2012-04
期刊：
North American journal of medical sciences
影响因子：
--
作者：
Goyal R;Faizy AF;Siddiqui SS;Singhai M
通讯作者：
Singhai M
影响因子：
8.2
作者：
Pickup, JC;Crook, MA
通讯作者：
Crook, MA