Cryptococcus Neoformans Meningitis Cases Among China's HIV-Infected Population may have been Severely Under-Reported.

Cryptococcus Neoformans Meningitis Cases Among China's HIV-Infected Population may have been Severely Under-Reported.
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DOI:
10.1007/s11046-020-00491-4
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发表时间:
2020-12
期刊:
影响因子:
5.5
通讯作者:
Xu J
Xu J
中科院分区:
生物学3区
文献类型:
--
作者:
Chen M;Xu N;Xu J

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隐球菌性脑膜炎(CM)是中枢神经系统的主要真菌感染。在全球范围内,报告的大多数CM病例来自免疫力低下的患者,特别是那些感染了艾滋病毒的患者。然而,来自中国的报告显示,大多数CM感染来自hiv阴性、免疫功能正常的宿主。在这里,我们回顾了已发表的报告,发现这些研究几乎完全基于来自中国大学附属医院的患者,而不是来自大多数中国艾滋病毒感染者接受治疗的专业传染病医院的患者。因此,我们认为中国hiv感染人群中的CM病例可能被严重低估。需要对专业传染病医院的CM病例进行分析,以确定中国CM的真实流行病学模式。
Cryptococcal meningitis (CM) is the leading fungal infection of the central nervous system. Globally, most CM cases have been reported from patients with compromised immunities, especially those infected with HIV. However, reports from China have shown that most CM infections were from HIV-negative, immunocompetent hosts. Here, we reviewed the published reports and found those studies were almost exclusively based on patients from hospitals associated with Chinese universities but not from specialized infectious diseases hospitals where most Chinese HIV-infected patients have been treated. Thus, we believe CM cases among China’s HIV-infected population may have been severely under-reported. Analyses of CM cases in specialized infectious diseases hospitals are needed to identify the true epidemiological pattern of CM in China.
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